Results 71 to 80 of about 471,211 (302)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Practical Implementation of Machine tool Metrology and Maintenance Management Systems

, 2012
Maximising asset utilisation and minimising downtime and waste are becoming increasingly important to all manufacturing facilities as competition increases and profits decrease.
Willoughby, P., Longstaff, Andrew P., Longstaff, A. P., Fletcher, Simon, Willoughby, Peter, Perkins, C., Perkins, Christopher, Fletcher, S.   +7 more
core   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

A systematic study on the dynamic recrystallization behavior of S55C during hot deformation

Journal of Materials Research and Technology
The hot deformation behavior of S55C steel was systematically investigated via isothermal compression tests over a temperature range of 850–1000 °C and a strain rate range of 0.01–10 s−1.
Wenshuai Yan, Qingle Hao, Yuting Zhou, Junhui Song, Kaipeng Zhao, Weimin Long   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A Closure Contact Model of Self-Affine Rough Surfaces Considering Small-, Meso-, and Large-Scale Stage Without Adhesive

Fractal and Fractional
Contact interface is essential for the dynamic response of the bolted structures. To accurately predict the dynamic characteristics of bolted joint structures, a fractal extension of the segmented scale model, i.e., the JK model, is proposed in this ...
Tao Zhang, Yiming Wu, Xian Liu, Kai Jiang   +3 more
doaj   +1 more source

Multi-objective optimisation of machine tool error mapping using automated planning

, 2015
Error mapping of machine tools is a multi-measurement task that is planned based on expert knowledge. There are no intelligent tools aiding the production of optimal measurement plans.
Longstaff, Andrew P., Parkinson, Simon, Longstaff, A. P., Parkinson, S., Longstaff, A.P.   +4 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Innovative Service-Based Business Concepts for the Machine Tool Building Industry [PDF]

, 2009
Organised by: Cranfield UniversityDuring the last decade, machine tool building companies have been forced to put innovative offers on the market. Due to the technical features of their products and the prevailing organizational structures in this ...
Lay, G., Marvulli, S., Copani, G., Biege, S., Schröter, M.   +4 more
core  

Efficient estimation by FEA of machine tool distortion due to environmental temperature perturbations

, 2013
Machine tools are susceptible to exogenous influences, which mainly derive from varying environmental conditions such as the day and night or seasonal transitions during which large temperature swings can occur.
Mian, Naeem, Fletcher, Simon, S. Fletcher, Longstaff, A.P., Naeem S. Mian, Fletcher, S., Myers, Alan, Longstaff, Andrew P., Myers, A., Mian, Naeem S., A.P. Longstaff, Longstaff, Andrew, A. Myers   +12 more
core   +1 more source