Results 91 to 100 of about 5,306,001 (276)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Modeling and Experimental Analysis of the Transmission Error in Top-Hat Harmonic Drive Considering Manufacturing and Assembly Errors

Applied Sciences
Top-hat-type harmonic drives are widely used in industrial robots and high-end equipment due to their large hollow structure, high load capacity, and high precision.
Hepeng Ni, Mengchen Du, Yuhui Hou, Zhiqiang Liu, Luwei Liu, Chuanying Wang, Ying Zhang   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Effect of pulse frequency on microstructure and properties of laser additive manufactured Inconel 718

Journal of Materials Research and Technology
Laser additive manufacturing of Inconel 718 nickel-based superalloy (In718) typically results in coarse columnar grains, which adversely affect its mechanical properties.
Yuanjun Su, Jingjie Zhang, Guangchun Xiao, Hui Chen, Mingdong Yi, Zhaoqiang Chen, Hui Zhang, Chonghai Xu   +7 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Hybrid modelling and simulation of a computer numerical control machine tool feed drive [PDF]

, 2004
The paper presents a new approach to the modelling and simulation of a computer numerical control (CNC) machine tool feed drive. The hybrid model of the drive incorporates a distributed load, explicit damping factors and measured non-linear effects in ...
Pislaru, Crinela, Holroyd, Geoffrey, Ford, Derek G.   +2 more
core   +2 more sources

Defect Generation and Detection Strategy for Tempered Glass in Sample-Scarce Scenarios

Information
To address the challenge of defect detection in tempered glass panel production rising from sample scarcity, this paper proposes a few-shot detection methodology that integrates an enhanced Stable Diffusion model with Mask R-CNN.
Kai Hou, Jing-Fang Yang, Peng Zhang, Guang-Chun Xiao, Fei Wang, Run-Ze Fan, Xiang-Feng Liu   +6 more
doaj   +1 more source

Technological robot-Machine tool collaboration for agile production. [PDF]

Front Robot AI, 2022
Wabner M, Rentzsch H, Ihlenfeldt S, Otto A.   +3 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source