Results 51 to 60 of about 7,726,210 (354)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Research on cutting mechanism and process optimization method of gear skiving

Scientific Reports
The cutting force and cutting temperature have a significant impact on the service life and durability of gear skiving cutters. Due to unreasonable design, the existing process parameters lead to dramatically nonuniform cutting force and cutting ...
Peng Wang, Yuanchao Ni, Xiaoqiang Wu, Jiaxue Ji, Geng Li, Jiahao Wu   +5 more
doaj   +1 more source

Springback Prediction of Dieless Forming of AZM120 Sheet Metal Based on Constitutive Model

Metals, 2020
Springback control is a key issue of the sheet-metal-forming process. In this paper, the mechanism of sheet-metal-forming along the folding trajectory of the computer numerical control (CNC) four-side automatic panel bender was studied, based on the bend-
Zijin Wu, Junjie Gong, Yangdong Chen, Jinrong Wang, Yuanyuan Wei, Jianhe Gao   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Study on effect of drilling rotational speed and tool wear on chip evacuation of micro drilling of printed circuit board

Nihon Kikai Gakkai ronbunshu, 2016
In recent years, needs for micro drilling are increasing, accompanying the development of higher wiring density of printed circuit board (PCB). When drilling PCB for the purpose of making the electric through holes, it has been said that the drill ...
Hiromi YOSHIMURA, Yu KATAHIRA, Hidehito WATANABE, Taiju YAMASHITA   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A Dynamic Scheduling Method Combining Iterative Optimization and Deep Reinforcement Learning to Solve Sudden Disturbance Events in a Flexible Manufacturing Process

Mathematics
Unpredictable sudden disturbances such as machine failure, processing time lag, and order changes increase the deviation between actual production and the planned schedule, seriously affecting production efficiency. This phenomenon is particularly severe
Jun Yan, Tianzuo Zhao, Tao Zhang, Hongyan Chu, Congbin Yang, Yueze Zhang   +5 more
doaj   +1 more source

Analysis and optimization of nonlinear carrying performance of hydrostatic ram based on finite difference method and Runge–Kutta method

Advances in Mechanical Engineering, 2019
Analyzing of nonlinear carrying performance of hydrostatic ram is among key research questions to improve heavy machine tools because the machining precision will be directly influenced by it.
Yumo Wang, Zhifeng Liu, Qiang Cheng, Yongsheng Zhao, Yida Wang, Ligang Cai   +5 more
doaj   +1 more source

In‐process image of machine tools – Transient‐thermal and dynamic simulation of moving structures

Engineering Reports, 2022
The aim of structural mechanics simulation is to better represent the working accuracy of machine tools. The visualization is done in process, that is, during the machine movement.
Tim Kreißl, Joachim Regel, Markus Wabner, Matthias Putz   +3 more
doaj   +1 more source