Results 71 to 80 of about 8,730,293 (397)

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Effect of Hydrostatic Guideway on Reduction of Machine Tool Ram Vibration [PDF]

, 2018
The guideways provide translational movement of machine parts and have a major impact on the resulting utility properties of the ma-chine tools, such as machining accuracy, surface quality and productivity.
Lazák T., Stach E., Sulitka M.
core  

Analytical and experimental study of feed rate in high-speed milling [PDF]

, 2013
In the context of high-speed milling (HSM), during the machining process dynamic machine response has to be identified. To achieve this, we have to calculate the feed rate evolution in linear and circular interpolation according to dynamic performance of
Baili, Maher, Dessein, Gilles, Gassara, Bassem, Hbaieb, Moncef, Saï, Wassila Bouzid   +4 more
core   +3 more sources

Investigation on Machine Tools Energy Consumptions

, 2014
{"references": ["Jeffery B.Dahmus, Timothy G.Gutowski. Anhaeim, \"An Environmental\nAnalysis of Machining,\". ASME International Mechanical Engineering\nCongress and RD&D Expo, 2004.", "Wen Li, Andre Zein, Sami Kara, Christoph Herrmann, \"An Investigation\ninto Fixed Energy Consumption of Machine Tools,\" 18th CRIP\nInternational conference on Life
Abdoli, Shiva, Semere Tesfamariam, Daniel   +1 more
openaire   +19 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

In‐process image of machine tools – Transient‐thermal and dynamic simulation of moving structures

Engineering Reports, 2022
The aim of structural mechanics simulation is to better represent the working accuracy of machine tools. The visualization is done in process, that is, during the machine movement.
Tim Kreißl, Joachim Regel, Markus Wabner, Matthias Putz   +3 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Analysis and optimization of nonlinear carrying performance of hydrostatic ram based on finite difference method and Runge–Kutta method

Advances in Mechanical Engineering, 2019
Analyzing of nonlinear carrying performance of hydrostatic ram is among key research questions to improve heavy machine tools because the machining precision will be directly influenced by it.
Yumo Wang, Zhifeng Liu, Qiang Cheng, Yongsheng Zhao, Yida Wang, Ligang Cai   +5 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A Dynamic Scheduling Method Combining Iterative Optimization and Deep Reinforcement Learning to Solve Sudden Disturbance Events in a Flexible Manufacturing Process

Mathematics
Unpredictable sudden disturbances such as machine failure, processing time lag, and order changes increase the deviation between actual production and the planned schedule, seriously affecting production efficiency. This phenomenon is particularly severe
Jun Yan, Tianzuo Zhao, Tao Zhang, Hongyan Chu, Congbin Yang, Yueze Zhang   +5 more
doaj   +1 more source