Results 71 to 80 of about 4,784,113 (302)
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Complementary Machining – Machining Strategy for Surface Modification
Procedia CIRP, 2016 AbstractIn metal production mechanical surface treatments are used to optimize workpiece characteristics like fatigue strength. Complementary Machining is a new machining strategy which is characterized by the combination of cutting and mechanical surface treatment.
Gerstenmeyer, Michael +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Investigations on Surface Integrity and Electrochemical Behavior of Machined Co-Cr-Mo Bio-implant Alloy [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2016 A decisive constraint for the long-term stability of the artificial joint is to minimize the release of debris particles. The wear/debris induced osteolysis and aseptic loosening are the result of failure of metal-on-metal joint implants.
K. A. Jagtap +2 more
doaj
, 2010 By high speed turning experiment of aerospace engine titanium alloy membrane discs, it researches cutting parameters influence on machined surface roughness of titanium alloy membrane discs, meanwhile measures and analyzes machined surface topography ...
Wei Zhang +3 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Influence of motion error of feed drive systems onto machined surface generated by ball end mill
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014 Although glitches due to motion error of the feed drive systems are typically observed on the machined surface, the relationships between the motion error and glitches are not investigated up to now.
Yuki SATO, Ryuta SATO, Keiichi SHIRASE
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Наука и техника, 2005 The paper considers regularities of machined surface formation and its wear resistance in the process of needle milling of baked ПА-ЖГр2 material. Roughness of the machined surface is reduced as feed and tightness are increased.
E. E. Feldshtejn +2 more
doaj +1 more source
Evaluation of the influence of grinding wheel stereometric features on the machined surface quality [PDF]
, 2009 W artykule przedstawiono analizy wpływu rozmieszczenia ziaren na powierzchni ściernicy na jakość powierzchni obrobionej z wykorzystaniem symulacji komputerowej procesu szlifowania opracowanej przez autorów.
Królikowski, T., Bałasz, B.
core