Results 141 to 150 of about 3,516,494 (408)

Dream Machines

open access: yesReviews of Accelerator Science and Technology, 2019
Particle accelerators and their detectors are the world’s most powerful microscopes. They enable us to inspect the constituents of matter at attometer scales, study matter under unusual conditions, and concentrate extraordinary amounts of energy into tiny volumes to create new forms of matter and initiate new phenomena.
openaire   +3 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

Material microstructure affected machining: a review

open access: yes, 2017
The machining induced material microstructure evolution path is determined from the temperature and mechanical loading history. Inversely, the machining forces and machined part surface integrity are dependent on the material microstructure attributes ...
Z. Pan, Yixuan Feng, S. Liang
semanticscholar   +1 more source

Machine Coaching

open access: yesProceedings of the IJCAI 2019 Workshop on Explainable Artificial Intelligence, 2019
This position paper puts forward machine coaching as a form of interactive machine learning that emphasizes the requirement for humans and machines to externalize their internal reasoning process in a manner that is understandable, at least at a basic level, by the other party.
openaire   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Recent advances in micro- and nano-machining technologies

open access: yes, 2017
Device miniaturization is an emerging advanced technology in the 21st century. The miniaturization of devices in different fields requires production of micro- and nano-scale components. The features of these components range from the sub-micron to a few
Shang Gao, Han Huang
semanticscholar   +1 more source

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