Results 51 to 60 of about 6,927 (264)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

On gaps in the reference literature on electrical machines

Collection of Scientific Publications NUS, 2015
Исследованы возможности сокращения трудоемкости энергетических расчетов в электроприводе при использовании информации о КПД и сos φ в частичных режимах электродвигателя. Показано на конкретных примерах, что использование указанной информации позволяет построить электромеханические и  энергетические характеристики электродвигателя, оценить количественно
Valentyn I. Lokariev, Dmytro V. Poprotskyi   +1 more
openaire   +2 more sources

Metaheuristic Approach of Multi-Objective Optimization during EDM Process [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2018
In modern-day manufacturing Electric Discharge Machining (EDM) process has successfully placed itself in the domain of precision machining and generating complex geometries where secondary machining processes are eliminated. In this research paper, a die
Goutam Kumar Bose, Pritam Pain
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Design of experiments integrated with neural networks for optimization and predictive modelling of electrode wear of novel Ti-6Al-4V-SiCp composites during die sinking electric discharge machining

Materials Research Express
Die Sink Electric Discharge Machining is a widely used manufacturing process for shaping hard and electrically conductive materials. This study investigates the effects of various electrode materials such as, Ti-6Al-4V-SiCp, Brass and Copper on the ...
Adithya Hegde, Raviraj Shetty, Rajesh Nayak, Sawan Shetty   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Electrochemical Machining Analysis of Aeroengine Blade Based on Isogeometric Method

Advances in Mechanical Engineering, 2015
Electrochemical machining is an important method for the blade in aeroengine. Analysis of electric field in machining gap is the basis of cathode design.
Neng Wan, Ke Du, Rong Mo, Tao Chen
doaj   +1 more source