Results 61 to 70 of about 6,927 (264)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Energy Demand Modeling Methodology of Key State Transitions of Turning Processes
Energies, 2017 Energy demand modeling of machining processes is the foundation of energy optimization. Energy demand of machining state transition is integral to the energy requirements of the machining process.
Shun Jia +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
AIP AdvancesWaspaloy, a nickel-based super alloy, has much potential in gas turbine component production. Machining this type of material using the traditional manufacturing method is very hard.
G. Veerappan +8 more
doaj +1 more source
EPJ Web of Conferences, 2015 The paper presents the results of experimental studies of electrochemical machining process oriented on occurring in the treatment critical states caused by electrolyte flow hydrodynamic conditions in the gap between electrodes.
Sawicki Jerzy, Paczkowski Tomasz
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
International Journal of Current Research in Science, Engineering & TechnologyThe relationship between Mathematics, Science and Technology is complex. Science is a conceptual construct that maintains a relationship of equivalence with observable reality, involving many experimental methods. This equivalence allows for the quantitative models that constitute scientific knowledge and technological development, which are Theories ...
openaire +1 more source
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018 Machining characteristics of electrochemical machining with ultrashort pulses were investigated using numerical analysis considering the inductance of a power supply circuit. In a pulse power supply circuit of ECM, stray inductance occurs in the electric
Tomohiro KOYANO +2 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source