Results 71 to 80 of about 6,927 (264)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Research on Theoretical Model of Combined Micro-Machining of Laser and Electrolysis of Thermal Barrier Coated Turbine Blade Film Cooling Holes

International Journal of Electrochemical Science, 2016
In view of high quality machining demand of thermal barrier coated turbine blade film cooling holes, a new method of combined micro-machining of laser and electrolysis is presented in this thesis.
Aixi Sun, Yulan Hu, Bo Hao
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Optimizing WEDM Parameters Using Swarm Intelligence: A Multi‐Objective Approach to Improve Machinability and Cost‐Efficiency

Engineering Reports
This study aims to optimize the Wire‐Cut Electrical Discharge Machining (WEDM) parameters for Inconel 800, a high‐performance superalloy known for its remarkable mechanical properties and resistance to elevated temperatures.
Abhijit Bhowmik, Raman Kumar, Nikunj Rachchh, T. Ramachandran, A. Karthikeyan, Rahul Singh, Deepak Gupta, Dhirendra Nath Thatoi, Bhavik Jain, A. Johnson Santhosh   +9 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Optimization of Surface Roughness for Al-alloy in Electro-chemical Machining (ECM) using Taguchi Method

Journal of Engineering, 2017
Electro-chemical Machining is  significant  process to remove metal with using  anodic dissolution. Electro-chemical machining use to removed metal workpiece from (7025) aluminum alloy using Potassium chloride (KCl) solution .The tool used was made from ...
Mostafa Adel Abdullah, Ass. Lect., Shukry Hammed Aghdeab, Ass. Prof. Dr., Safaa Kadhim Ghazi, Ass. Lect.   +2 more
doaj   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Optimization of Process Parameters in Electropolishing of SS 316L Utilizing Taguchi Robust Design

Journal of Manufacturing and Materials Processing
In electropolishing, the material removal rate is frequently neglected, as this process is primarily focused on surface finish, and yet, it is crucial for manufacturing metallic sheets.
Muhammad Kemal Syahputra, Kartika Nur ‘Anisa’, Rizky Astari Rahmania, Farazila Yusof, Pradeep Dixit, Muslim Mahardika, Gunawan Setia Prihandana   +6 more
doaj   +1 more source