Results 81 to 90 of about 6,927 (264)
Nonconventional Technologies Review, 2023 Electrochemical machining is a machining method that uses electrochemical reactions to remove material from a workpiece. The method involves using an electrolyte and an electric current for material removal to occur in a controlled manner. The machining
Daniela Ciobanu +5 more
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Alexandria Engineering Journal, 2018 The foremost aim of Electrical Discharge Machining (EDM) users and manufactures is to obtain a better process stability, maximum productivity, precise and accurate machining of the component with minimum tool wear. For achieving better efficiency in EDM,
Vijaykumar S. Jatti
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
GREY RELATIONAL ANALYSIS AND ITS APPLICATION ON SURFACE PROPERTIES DURING EDM AND POWDER MIXED EDM [PDF]
Journal of Engineering Science and Technology, 2017 Electrical discharge machining is an extensively used non-conventional process for material removal in die manufacturing and aerospace industries. The mechanism of powder mixed electric discharge machining is very different from that of electrical ...
S. TRIPATHY, D. K.TRIPATHY
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Al-Qadisiyah Journal for Engineering Science, 2014 Micro-EDM is one of an important process in machining holes which is used in wide applications to fabricate medical devices and small dies.20 samples were run by using CNC EDM machine was used for machining of conducting materials such as copper alloy ...
Dr. Shukry H. Aghdeab +1 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source