Results 111 to 120 of about 12,418 (275)

A P-local Delooping Machine

, 2015
We show that for spaces $A$ that satisfy a certain smallness condition, there is a Lawvere theory $T_A$ so that a space $X$ has the structure of a $T_A$-algebra if and only if $X$ is weakly equivalent to a mapping space out of $A$. In particular, spheres localized at a set of primes satisfy this condition.
openaire   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Wannier-Stark ladders in one-dimensional elastic systems

, 2006
The optical analogues of Bloch oscillations and their associated Wannier-Stark ladders have been recently analyzed. In this paper we propose an elastic realization of these ladders, employing for this purpose the torsional vibrations of specially ...
A. Díaz-de-Anda, A. Morales, C. Zener, F. Bloch, G. Monsivais, G. H. Wannier, J. Flores, K. F. Graff, L. Gutiérrez, R. A. Méndez-Sánchez   +9 more
core   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Self-excited vibrations in turning: cutting moment analysis

, 2009
This work aims at analysing the moment effects at the tool tip point and at the central axis, in the framework of a turning process. A testing device in turning, including a six-component dynamometer, is used to measure the complete torsor of the cutting
Albert, Gaëtan, Bisu, Claudiu F., Cahuc, Olivier, Darnis, Philippe, Gérard, Alain, Gérard, Céline, K'Nevez, Jean-Yves   +6 more
core   +6 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Through-mask electrochemical machining of micro-dimple arrays with synchronization of power switching and cathode movements

Advances in Mechanical Engineering
Micro-dimple arrays with specific shapes and dimensions are crucial for reducing wear and vibration. Through-mask electrochemical machining (TMECM) using flexible cathodes removes materials based on anodic dissolution and allows for efficient processing ...
Feng Wang, Xinke Yuan, Tao Wang, Yiqing Wan, Yafeng He, Min Kang   +5 more
doaj   +1 more source