Results 81 to 90 of about 43,039 (317)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identification of influent factors on surface integrity in nickel-base superalloy drilling [PDF]

, 2010
For the critical rotating components in aeronautical industry, the metallurgical quality achieved after machining conditions could determine their mechanical behaviour in fatigue. To guarantee this quality, the tools, materials and cutting conditions are
Dutilh, Vincent, Baili, Maher, Popa, Andreï, Dessein, Gilles, Perrin, Géraldine   +4 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

ANNs Prediction of Input Parameters Dutiny PMMA Laser Micro-machining [PDF]

, 2016
This paper presents usage of artificial neural networks for modelling of laser micro-machining process. Results of the laser micro-machining – surface quality of product and his utility in specific application – depend on the laser-machine parameters and
Sýkorová, Libuše, Sámek, David
core  

A CNC Turning Process Simulation for a Polygonal Shaft Using CAM ESPRIT Software

Engineering Proceedings
Machining process simulation is a method to increase machining quality and efficiency. The right cutting tool geometry and parameters are chosen during the machining simulation process to create a variety of precision component shapes.
Yanyan Achmad Hoesen, Maulana Furqon, Novrinaldi, Umi Hanifah, Nur Arifudin Rofik   +4 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Three-Stage Optimization of Surface Finish in WEDM of D2 Tool Steel via Taguchi Design and ANOVA Analysis

Metals
Wire electrical discharge machining (WEDM) is a standard micro-manufacturing technology. In WEDM, surface roughness (SR), deviation dimension (DD), and machining time (MT) are critical requirements that impact machining quality and are affected by ...
Thanh Tan Nguyen, Bui Phuoc Phi, Van Tron Tran, Van-Thuc Nguyen, Van Thanh Tien Nguyen   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Effect of different parameters on machining of SiC/SiC composites via pico-second laser [PDF]

, 2016
Pico-second laser plays an important role in modern machining technology, especially in machining high hardness materials. In this article, pico-second laser was utilized for irradiation on SiC/SiC composites, and effects of different processing ...
Li, Weinan, Zhang, Ruoheng, Cheng, Laifei, Wang, Chunhui, Liu, Yongsheng, Yang, Xiaojun, Wang, Jing   +6 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source