Results 161 to 170 of about 13,279 (251)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Dipyridinophane ligands - synthesis and coordination study. [PDF]

RSC Adv
Kuncová L, Lazarová J, Kotek J, Kubíček V, Hermann P.   +4 more
europepmc   +1 more source

Hydroxyaldehyde and formyl photoproducts of protoporphyrin IX formed under photodynamic diagnosis and therapy irradiation conditions

Photochemistry and Photobiology, EarlyView.
Photoproducts of the photosensitizer protoporphyrin IX (PpIX) may have diagnostic and therapeutic relevance in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These photoproducts possess fluorescence and photosensitizing properties and could serve as a complementary dosimetry index alongside photosensitizer photobleaching. The formation of
Sochi J. Ogbonna, Katsuyoshi Masuda, Hisanao Hazama   +2 more
wiley   +1 more source

CO₂ Adsorption Capabilities of Functionalized Dyn[4]arenes. [PDF]

ACS Omega
Alektoridis K, Rauls E.
europepmc   +1 more source

Advances in organic UV filters for sunscreens over the past decade

Photochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon, Maria Carolina Theisen, Andressa Motta Castro, Giovana Jones Radke, Fernando Fumagalli   +4 more
wiley   +1 more source

A Bambusuril That Responds to Anion Binding in Its Absorption Spectrum. [PDF]

J Org Chem
Grunová M, Bautista Dela Cruz JA, Slávik P, Šindelář V.   +3 more
europepmc   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Macrocyclic Molecular Glues for the 14-3-3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship. [PDF]

Angew Chem Int Ed Engl
Pennings MAM, van den Bosch MAW, Oberheide A, Verhoef CJA, Ottmann C, Markvoort AJ, Miley GP, Brunsveld L.   +7 more
europepmc   +1 more source

Sex differences in dynamic cerebral autoregulation responses to resistance and endurance training in humans

Experimental Physiology, EarlyView.
Abstract Exercise maintains brain health and reduces the risk of cerebrovascular diseases, such as stroke and dementia. The benefits of different ‘modalities’ of exercise on male and female cerebral autoregulation are unclear. In this study, we compared adaptations in dynamic cerebral autoregulation (dCA) during spontaneous and forced oscillations in ...
Hannah J. Thomas, Channa E. Marsh, Leanne Lester, Louise H. Naylor, Kurt J. Smith, Daniel J. Green   +5 more
wiley   +1 more source

Precision Switching and Coupled Motion in a [3]Rotaxane Molecular Machine

Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.
A [3]rotaxane, composed by two crown ether macrocycles and an axle presenting three recognition sites, is operated through both chemical and electrochemical stimuli. The position of the macrocycles is precisely controlled by sequential stimulation and the processes are fully reversible. The characterization of the system revealed the macrocycles affect
Leonardo Andreoni, Jessica Groppi, Alberto Credi, Serena Silvi   +3 more
wiley   +2 more sources