Results 141 to 150 of about 13,257 (251)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Interaction between Paracetamol Glucuronide and a Glucose-Sensitive Insulin Molecule (NNC2215): Increased Risk of Hypoglycemia. [PDF]

ACS Pharmacol Transl Sci
Sturis J, Alifrangis L, Nielsen PK, Lykke L, Björkbom A, Hvidt M, Brand CL, Kruse T, Johansson E, Granata D, Petersen BO, Rodríguez D, Madsen AR, Halskov KS, Hansen A, Koščová S, Kotek V, Tarus V, Fels JJ, Niclasen AV, Chapman A, Sauerberg P, Slaaby R.   +22 more
europepmc   +1 more source

Hydroxyaldehyde and formyl photoproducts of protoporphyrin IX formed under photodynamic diagnosis and therapy irradiation conditions

Photochemistry and Photobiology, EarlyView.
Photoproducts of the photosensitizer protoporphyrin IX (PpIX) may have diagnostic and therapeutic relevance in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These photoproducts possess fluorescence and photosensitizing properties and could serve as a complementary dosimetry index alongside photosensitizer photobleaching. The formation of
Sochi J. Ogbonna, Katsuyoshi Masuda, Hisanao Hazama   +2 more
wiley   +1 more source

A new class of customisable stable boronic ester assemblies. [PDF]

Chem Sci
Coomber D, Rusli O, Sharma H, Lee HE, Evans JD, Rijs NJ, Hua C, Pfeffer F.   +7 more
europepmc   +1 more source

Advances in organic UV filters for sunscreens over the past decade

Photochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon, Maria Carolina Theisen, Andressa Motta Castro, Giovana Jones Radke, Fernando Fumagalli   +4 more
wiley   +1 more source

Chain Versus Ring: Characterization of a Meta-Phenylene Ladder Polymer and Its Octameric Macrocycle. [PDF]

Chemistry
Barradas PDN, Jötten HJ, Nguyen NBB, Scherf U, de Seixas de Melo JS.   +4 more
europepmc   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Recent Advancements in Information Ratchet Design. [PDF]

Molecules
Incarbone S, De Gioia L.
europepmc   +1 more source

Sex differences in dynamic cerebral autoregulation responses to resistance and endurance training in humans

Experimental Physiology, EarlyView.
Abstract Exercise maintains brain health and reduces the risk of cerebrovascular diseases, such as stroke and dementia. The benefits of different ‘modalities’ of exercise on male and female cerebral autoregulation are unclear. In this study, we compared adaptations in dynamic cerebral autoregulation (dCA) during spontaneous and forced oscillations in ...
Hannah J. Thomas, Channa E. Marsh, Leanne Lester, Louise H. Naylor, Kurt J. Smith, Daniel J. Green   +5 more
wiley   +1 more source

The Missing Element in the World of Macrocycles─<i>p</i>-Pyriporphyrin. [PDF]

Org Lett
Kamyszek J, Myśliborski R, Modelska D, Krzyszowska P, Białek MJ, Gordel-Wójcik M, Chmielewski PJ, Latos-Grażyński L, Hurej K.   +8 more
europepmc   +1 more source