Results 121 to 130 of about 13,257 (251)

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Massive barcode-free chemical screenings enable the discovery of bioactive macrocycles with passive membrane permeability. [PDF]

Nat Commun
Mata JM, Liu J, McKenna SM, van der Nol E, Havermans M, Delwel R, Filius M, Joo C, Vallaro M, Caron G, Pomplun SJ.   +10 more
europepmc   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Orthogonal cation and anion template-directed synthesis of a heteroditopic [3]catenane for ion-pair recognition. [PDF]

Chem Sci
Tay HM, Docker A, Martínez-Martínez AJ, Beer PD.   +3 more
europepmc   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Covalent-Bond-Directed Synthesis of Rotaxanes from Macrocyclic Diaryliodonium Salts. [PDF]

Org Lett
Hamamura K, Nakamura A, Mutoh Y, Yoshigoe Y, Kawasaki T, Hosoya S, Saito S.   +6 more
europepmc   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

A Longitudinal Evaluation of Bone Mineral Density Across a Macrocycle in Highly Trained Female Athletes: A Systematic Review. [PDF]

Sports (Basel)
Black GM, Wells M, Devlin BL.
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Orientation of the Electronic Qy Transition Dipole Moment in Chlorophyll a. [PDF]

J Phys Chem B
Zahn C, Nag P, Stensitzki T, Müller-Werkmeister H, Schapiro I, Heyne K.   +5 more
europepmc   +1 more source