Results 131 to 140 of about 13,279 (251)

A dual-responsive cationic acridinium nanohoop: redox activity and acid/base-controlled reversible guest capture and release. [PDF]

Chem Sci
Ming J, Zhang J, Hu Y, Lan K, Zhang D, Li P, Miao J, Jiang J, Zhang X, Zhong H, Yu P, Cheng C.   +11 more
europepmc   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Interaction between Paracetamol Glucuronide and a Glucose-Sensitive Insulin Molecule (NNC2215): Increased Risk of Hypoglycemia. [PDF]

ACS Pharmacol Transl Sci
Sturis J, Alifrangis L, Nielsen PK, Lykke L, Björkbom A, Hvidt M, Brand CL, Kruse T, Johansson E, Granata D, Petersen BO, Rodríguez D, Madsen AR, Halskov KS, Hansen A, Koščová S, Kotek V, Tarus V, Fels JJ, Niclasen AV, Chapman A, Sauerberg P, Slaaby R.   +22 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

A new class of customisable stable boronic ester assemblies. [PDF]

Chem Sci
Coomber D, Rusli O, Sharma H, Lee HE, Evans JD, Rijs NJ, Hua C, Pfeffer F.   +7 more
europepmc   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Chain Versus Ring: Characterization of a Meta-Phenylene Ladder Polymer and Its Octameric Macrocycle. [PDF]

Chemistry
Barradas PDN, Jötten HJ, Nguyen NBB, Scherf U, de Seixas de Melo JS.   +4 more
europepmc   +1 more source

Dynamic Polydisulfide Latex via Emulsion Ring‐Opening Polymerization of Cyclodisulfides

Journal of Polymer Science, EarlyView.
A polydisulfide latex with a high molar mass was achieved by emulsion polymerization process starting from a dithiol. The mechanism reveals an entropy‐driven ring‐opening polymerization involving disulfide macrocycle intermediates. The polydisulfide particles can be degraded by thiol‐disulfide exchange, and the disulfide fragments can be reengaged in a
Sandric Afonso, Pierre‐Louis Quentin, Marc Schmutz, Cécile Joyeux, Cuong Minh Quoc Le, Abraham Chemtob   +5 more
wiley   +1 more source

Recent Advancements in Information Ratchet Design. [PDF]

Molecules
Incarbone S, De Gioia L.
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source