Results 11 to 20 of about 13,257 (251)
Synlett, 2018 Artificial macrocycles recently became popular as a novel research field in drug discovery. As opposed to their natural twins, artificial macrocycles promise to have better control on synthesizability and control over their physicochemical properties resulting in druglike properties. Very few synthetic methods allow for the convergent, fast but diverse
Abdelraheem +3 more
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Symmetric Macrocycles by a Prins Dimerization and Macrocyclization Strategy [PDF]
Organic Letters, 2009 A tandem dimerization/macrocyclization reaction utilizing the Prins cyclization has been developed. This reaction develops molecular complexity through the formation of highly substituted dimeric tetrahydropyran macrocycles. Mild conditions utilizing rhenium(VII) catalysts were explored for aromatic substrates, while harsher Lewis acidic conditions ...
Michael R, Gesinski +2 more
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Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles [PDF]
Molecules, 2013 Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized. The construction of macrocycles is generally considered as a crucial and challenging step in the synthesis of macrocyclic natural products.
Xufen Yu, Dianqing Sun
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Beilstein Journal of Organic Chemistry, 2019 Two new tetralactam macrocycles with 2,3-dibutoxynaphthalene groups as sidewalls have been synthesized and characterized. The macrocycle containing isophthalamide bridges can bind square-planar chloride coordination complexes of gold(III), platinum(II ...
Li-Li Wang +3 more
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Photosensitizers Mediated Photodynamic Inactivation against Fungi
Nanomaterials, 2021 Superficial and systemic fungal infections are essential problems for the modern health care system. One of the challenges is the growing resistance of fungi to classic antifungals and the constantly increasing cost of therapy.
Daniel Ziental +4 more
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A ferrocene redox-active triazolium macrocycle that binds and senses chloride
Beilstein Journal of Organic Chemistry, 2012 A ferrocene bis(triazole) macrocycle was synthesised in good yield by the Eglinton coupling of an acyclic bis(alkyne) precursor and characterised in the solid state by X-ray crystallography. Alkylation gives the corresponding triazolium macrocycle, which
Nicholas G. White, Paul D. Beer
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Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, [Hg3(C6F4)3]·C6N4, contains one molecule of tetracyanoethylene B per one molecule of mercury macrocycle A, i.e., A•B, and crystallizes in the monoclinic space group C2/c.
Raúl Castañeda +2 more
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Frontiers in Molecular Biosciences, 2022 Technologies for discovering peptides as potential therapeutics have rapidly advanced in recent years with significant interest from both academic and pharmaceutical labs.
Jeffrey K. Holden +4 more
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Molecules, 2022 The controlled synthesis of organometallic supramolecular macrocycles cages remains interesting and challenging work in the field of supramolecular chemistry.
Li-Long Dang +6 more
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Spectral manifestation of substitution of out-of-plane ligands in metallophtalocyanines
EPJ Web of Conferences, 2017 In our study, we demonstrate the splitting effect of long-wavelength bands in absorption spectra (excitation of fluorescence) of the series of Zn(II), Ti(IV), Zr(IV) and Hf(IV) phthalocyanines at low temperatures.
Starukhin A. +6 more
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