Results 21 to 30 of about 13,279 (251)
Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles [PDF]
Molecules, 2013 Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized. The construction of macrocycles is generally considered as a crucial and challenging step in the synthesis of macrocyclic natural products.
Xufen Yu, Dianqing Sun
openaire +3 more sources
Acta Chimica Slovenica, 2017 With the application of a double dienophile 1,1'-(hexane-1,6-diyl)bis(1H-pyrrole-2,5-dione) for a [4+2] cycloaddition with a substituted 2H-pyran-2-one a novel 26-membered tetraaza heteromacrocyclic system 3 was prepared via a direct method under solvent-
Bor Lucijan Turek +3 more
doaj +1 more source
Investigation of Structural Mimetics of Natural Phosphate Ion Binding Motifs
Molecules, 2015 Phosphates are ubiquitous in biology and nearly half of all proteins interact with their partners by means of recognition of phosphate residues. Therefore, a better understanding of the phosphate ion binding by peptidic structures is highly desirable ...
Evgeny A. Kataev, Tatiana A. Shumilova
doaj +1 more source
Molecules, 2022 The NIS synthetase family of enzymes responsible for the biosynthesis of siderophores is increasingly associated with bacterial virulence. Proteins in this class represent outstanding potential drug targets, assuming that basic biochemical and structural
Katherine M. Hoffmann +5 more
doaj +1 more source
Heterocyclic Communications, 2019 Novel magnesium(II) porphyrazine with peripheral methyl(3,5-dibromophenylmethyl)amine groups was synthesized in a multi-step procedure starting from commercially available diaminomaleonitrile. All intermediates and the final macrocycle were characterized
Wieczorek Ewelina +5 more
doaj +1 more source
Five-component, one-pot synthesis of an electroactive rotaxane comprising a bisferrocene macrocycle
Beilstein Journal of Organic Chemistry, 2020 The templated clipping of a ferrocene-grafted isophthalic acid derivative to encircle a hydrogen-bonding axle through the reaction with 1,4-bis(aminomethyl)benzene is described.
Natalie Lagesse +6 more
doaj +1 more source
Effect of ring rize on photoisomerization properties of stiff stilbene macrocycles
Beilstein Journal of Organic Chemistry, 2019 A series of stiff stilbene macrocycles have been studied to investigate the possible impact of the macrocycle ring size on their photodynamic properties.
Sandra Olsson +3 more
doaj +1 more source
Bambusuril analogs based on alternating glycoluril and xylylene units
Beilstein Journal of Organic Chemistry, 2019 The glycoluril monomer is a popular building block in supramolecular chemistry as it is used for the synthesis of versatile host molecules which can interact with cationic, anionic or neutral guest molecules. Here we present the design and synthesis of a
Tomáš Lízal, Vladimír Šindelář
doaj +1 more source
Frontiers in Chemistry, 2018 In the interdisciplinary research field of chemical biology and drug discovery, diversity-oriented synthesis (DOS) has become indispensable in the construction of novel small-molecule libraries rich in skeletal and stereochemical diversity.
Sihyeong Yi +3 more
doaj +1 more source
Perfection of the functional readiness of high-qualified athletes in the process of preparation for international competitions [PDF]
Слобожанський науково-спортивний вісник, 2018 Purpose: to evaluate the effectiveness of using the program of building the training process in the preparatory period of the annual macrocycle for improving the functional fitness of the athletes of the Ukrainian national track and field team in ...
Svetlana Karaulova , Nikolai Malikov
doaj +1 more source