Results 21 to 30 of about 29,916 (207)
Molecules, 2022 The controlled synthesis of organometallic supramolecular macrocycles cages remains interesting and challenging work in the field of supramolecular chemistry.
Li-Long Dang +6 more
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Symmetric Macrocycles by a Prins Dimerization and Macrocyclization Strategy [PDF]
Organic Letters, 2009 A tandem dimerization/macrocyclization reaction utilizing the Prins cyclization has been developed. This reaction develops molecular complexity through the formation of highly substituted dimeric tetrahydropyran macrocycles. Mild conditions utilizing rhenium(VII) catalysts were explored for aromatic substrates, while harsher Lewis acidic conditions ...
Michael R, Gesinski +2 more
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Formation of a macrocycle from dichlorodimethylsilane and a pyridoxalimine Schiff base ligand
Acta Crystallographica Section E: Crystallographic Communications, 2021 The reaction of dichlorodimethylsilane with a polydentate Schiff base ligand derived from pyridoxal and 2-ethanolamine yielded the macrocyclic silicon compound (8E,22E)-4,4,12,18,18,26-hexamethyl-3,5,17,19-tetraoxa-8,13,22,27-tetraaza-4,18-disilatricyclo[
Uwe Böhme +2 more
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Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles [PDF]
Molecules, 2013 Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized. The construction of macrocycles is generally considered as a crucial and challenging step in the synthesis of macrocyclic natural products.
Xufen Yu, Dianqing Sun
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A heterometallic macrocycle as a redox-controlled molecular hinge [PDF]
, 2015 The ability to modify the structure of nanoscopic assemblies in a controlled fashion is an important prerequisite for the creation of functional supramolecular systems.
Schouwey, Clément +7 more
core +1 more source
Acta Chimica Slovenica, 2017 With the application of a double dienophile 1,1'-(hexane-1,6-diyl)bis(1H-pyrrole-2,5-dione) for a [4+2] cycloaddition with a substituted 2H-pyran-2-one a novel 26-membered tetraaza heteromacrocyclic system 3 was prepared via a direct method under solvent-
Bor Lucijan Turek +3 more
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Investigation of Structural Mimetics of Natural Phosphate Ion Binding Motifs
Molecules, 2015 Phosphates are ubiquitous in biology and nearly half of all proteins interact with their partners by means of recognition of phosphate residues. Therefore, a better understanding of the phosphate ion binding by peptidic structures is highly desirable ...
Evgeny A. Kataev, Tatiana A. Shumilova
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Molecules, 2022 The NIS synthetase family of enzymes responsible for the biosynthesis of siderophores is increasingly associated with bacterial virulence. Proteins in this class represent outstanding potential drug targets, assuming that basic biochemical and structural
Katherine M. Hoffmann +5 more
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Development of macrocycle-based ligands for challenging disease targets
, 2022 reservedMacrocycles are a promising class of therapeutics because they can bind targets considered undruggable with small molecules. A focused KRAS macrocycle library designed and synthesized to make smaller and potent KRAS (G12D) inhibitors using the ...
COVATO, ELENA
core
Heterocyclic Communications, 2019 Novel magnesium(II) porphyrazine with peripheral methyl(3,5-dibromophenylmethyl)amine groups was synthesized in a multi-step procedure starting from commercially available diaminomaleonitrile. All intermediates and the final macrocycle were characterized
Wieczorek Ewelina +5 more
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