Results 121 to 130 of about 430,530 (226)

Synthesis and Characterization of Amido-Thiourea Based p-tert-butylcalix[4]arene Compound and Investigation of Transition Metal Complex Properties

Düzce Üniversitesi Bilim ve Teknoloji Dergisi
In host-guest complexes, the compatibility of the size and shape of the host cavity and the guest molecule is essential in the formation of the host-guest complex.
Sevil Söyleyici
doaj   +1 more source

Targeted Protein Degradation: From Molecular Mechanisms to Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Graphical overview of targeted protein degradation: mechanisms, molecular determinants, delivery strategies, and therapeutic development. This graphical abstract summarizes the major degradation pathways involved in targeted protein degradation, including the ubiquitin–proteasome system, endocytosis–lysosome pathway, and autophagy‐dependent degradation.
Huaijuan Guo, Haishuang Duan, Yang Liu, Kelan Fang, Lujia Xiao, Ling Bai, Xiao Qu, Xuebing Yan, Kun Zhang   +8 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Impact of Threading State on the Mechanics of γ‐Cyclodextrin–Pyrene Gels

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Tuning the threading state of discrete γ‐cyclodextrin (γ‐CD)–pyrene pseudorotaxane crosslinkers controls gel topology and ring mobility. The resulting doubly threaded slide‐ring networks exhibit solvent‐switchable dissipative dynamics, high extensibility, rate‐dependent mechanics, and low hysteresis, revealing how crosslink topology governs macroscopic
Jongwon Oh, Heyi Liang, Natsumi Nitta, Jongmin Kim, Yuan Tian, Guancen Liu, Jerald E. Hertzog, Juan J. de Pablo, Stuart J. Rowan   +8 more
wiley   +2 more sources

Sequential and Concurrent C5 and Neonatal Fc Receptor Inhibition in Prolonged Myasthenic Crisis due to Advanced Invasive Thymoma‐Associated Myasthenia Gravis: A Case Report and Literature Review

Clinical and Experimental Neuroimmunology, Volume 17, Issue 4, November 2026.
ABSTRACT Thymoma‐associated myasthenia gravis (TAMG) is frequently refractory, particularly when complicated by myasthenic crisis in advanced invasive disease. Complement C5 inhibitors and neonatal Fc receptor (FcRn) inhibitors have expanded the treatment of acetylcholine receptor (AChR) antibody‐positive generalized myasthenia gravis; however, their ...
Yuta Kizuka, Yuriko Nakamura, Kensuke Okada, Yu Okubo, Kaoru Kaseda, Hirofumi Toyama, Keisuke Asakura, Atsuya Takeda, Jin Nakahara, Kei Ishizuchi   +9 more
wiley   +1 more source

Synthesis, Physicochemical Characteristics, Self‐Assembly and Encapsulation Ability of per‐Ethylene‐Glycol‐Functionalized Resorcin[4]Arenes and Their Molecular Capsules: On the Road to Liquid Capsules

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
Per‐ethylene‐glycol (EG)‐functionalized resorcin[4]arenes containing 12, 16, and 20 EG groups namely compounds 1d, 1e, and 1f, respectively, were prepared and found to self‐assemble, in organic solvents, into hexameric capsules. These capsules are more dynamic than the ones prepared based on alkyl substituted resorcin[4]arenes.
Gangadhara Angajala, Inbar Horin, Tamar Evan‐Salem, Yoram Cohen   +3 more
wiley   +1 more source

Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle

Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.
Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou, Jinbiao Jiao, Mathieu Lordez, Jean‐Yves Salpin, Juan Xie   +4 more
wiley   +1 more source

Guest-dependent solid-state superstructure plasticity and its application to adsorptive benzene sieving. [PDF]

Chem Sci
Li M, Zhang Q, Zhang H, Vasylevskyi S, Ko MS, Cervantes JS, Huang F, Sessler JL.   +7 more
europepmc   +1 more source

Supramolecular complexes of dihydroazolopyrimidines with macrocyclic receptors: synthesis, rapid analysis, and evaluation. [PDF]

Beilstein J Org Chem
Miasnikova D, Saraiev V, Shvets O, Korobka A, Chernyaeva O, Sakhno Y, Vashchenko O, Shaposhnyk A, Chebanov VA.   +8 more
europepmc   +1 more source