The first report of macrocyclic lactone resistant cyathostomins in the UK [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2023 In recent years, resistance to the benzimidazole (BZ) and tetrahydropyrimidine (PYR) anthelmintics in global cyathostomin populations, has led to reliance on the macrocyclic lactone drugs (ML-of which ivermectin and moxidectin are licensed in horses) to ...
K.E. Bull +3 more
doaj +3 more sources
Moxidectin: heartworm disease prevention in dogs in the face of emerging macrocyclic lactone resistance [PDF]
Parasites & Vectors, 2022 Heartworm (Dirofilaria immitis) disease continues to increase and spread, remaining one of the most important and pathogenic parasitic diseases of dogs, despite the regular use of macrocyclic lactones (MLs) in preventive products.
Molly D. Savadelis +4 more
doaj +3 more sources
The macrocyclic lactone oxacyclododecindione reduces fibrosis progression [PDF]
Frontiers in Pharmacology, 2023 Background: Renal fibrosis is one of the most important triggers of chronic kidney disease (CKD), and only a very limited number of therapeutic options are available to stop fibrosis progression.
Sabrina Saurin +7 more
doaj +6 more sources
Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2020 Anthelmintic resistance in equine cyathostomins is both widespread and highly prevalent in the benzimidazole and tetrahydropyrimidine classes; however, reports of resistance to macrocyclic lactone (ML) drugs are sparse and sporadic.
M.K. Nielsen, M. Banahan, R.M. Kaplan
doaj +3 more sources
Strategies for the control of Rhipicephalus microplus ticks in a world of conventional acaricide and macrocyclic lactone resistance. [PDF]
Parasitol Res, 2018 Infestations with the cattle tick, Rhipicephalus microplus, constitute the most important ectoparasite problem for cattle production in tropical and subtropical regions worldwide, resulting in major economic losses. The control of R.
Rodriguez-Vivas RI +2 more
europepmc +4 more sources
A diagnostic algorithm for evaluating cases of potential macrocyclic lactone–resistant heartworm [PDF]
Parasites & Vectors, 2017 Background The emergence of macrocyclic lactone resistance in canine heartworm poses a substantial threat to what is currently the only effective, FDA-approved available method of prevention.
Andrew R. Moorhead +2 more
doaj +3 more sources
Laboratory assays reveal diverse phenotypes among microfilariae of Dirofilaria immitis isolates with known macrocyclic lactone susceptibility status. [PDF]
PLoS ONE, 2020 Prevention of canine heartworm disease caused by Dirofilaria immitis relies on chemoprophylaxis with macrocyclic lactone anthelmintics. Alarmingly, there are increased reports of D. immitis isolates with resistance to macrocyclic lactones and the ability
Jeba R J Jesudoss Chelladurai +5 more
doaj +3 more sources
First case of macrocyclic lactone-resistant Dirofilaria immitis in Europe - Cause for concern [PDF]
International Journal for Parasitology: Drugs and Drug ResistanceHeartworm disease caused by the nematode Dirofilaria immitis is one of the most important parasitoses of dogs. The treatment of the infection is long, complicated, risky and expensive.
Donato Traversa +8 more
doaj +3 more sources
Clinical validation of molecular markers of macrocyclic lactone resistance in Dirofilaria immitis [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2018 Prophylaxis with macrocyclic lactone (ML) endectocides is the primary strategy for heartworm control. Recent evidence has confirmed that ML-resistant Dirofilaria immitis isolates have evolved.
Cristina Ballesteros +5 more
doaj +3 more sources
Shifting the paradigm in Dirofilaria immitis prevention: blocking transmission from mosquitoes to dogs using repellents/insecticides and macrocyclic lactone prevention as part of a multimodal approach [PDF]
Parasites & Vectors, 2017 Background This study assessed the influence of a topical ectoparasiticide (dinotefuran-permethrin-pyriproxyfen, DPP, Vectra® 3D, Ceva Animal Health) combined with a macrocyclic lactone (milbemycin oxime, MBO, Interceptor®, Virbac) on transmission of ...
John W. McCall +8 more
doaj +3 more sources