Results 91 to 100 of about 442 (127)

Entropically Favorable Macrolactamization. Synthesis of Isodityrosine Peptide Analogues by Tandem Erlenmeyer Condensation−Macrolactamization

The Journal of Organic Chemistry, 1999
Macrolactams containing a modified isodityrosine moiety were assembled by direct addition of a bis-4-aryliden-5(4H)-oxazolone, derived by double Erlenmeyer condensation of diaryl ether dicarboxaldehydes and an α,ω-diamine, derived from the same precursor.
Karl L. Bailey, Tadeusz F. Molinski
openaire   +1 more source

ChemInform Abstract: Macrolactones and Macrolactams

ChemInform, 2010
AbstractReview: 164 refs.
Chang‐Liang Sun, Bi‐Jie Li, Zhang‐Jie Shi   +2 more
openaire   +1 more source

A facile and efficient method for macrolactamization

Tetrahedron Letters, 1990
Abstract Using 2-bromo-l-methylpyridinium iodide as carboxyl activating agent, 10 ansa-macrolactams were prepared conveniently from the corresponding seco-precursor ω-amino acids. In most cases the yields are excellent.
Donglu Bai, Yunxin Bo, Qiting Zhou
exaly   +2 more sources

A Synthetic Study of Dibenzo-Aromatic Macrolactams

HETEROCYCLES, 2010
Efforts to generate benzenoid macrolactams in the development of hybrid molecules as New Chemical Entities are described. The olefin metathesis protocol was adopted in facilitating the cyclization process.
David P. Brown, Thomas Wong
openaire   +1 more source

From azido acids to macrolactams and macrolactones

Journal of the Chemical Society, Chemical Communications, 1988
A new method is reported for the conversion of azido acids into lactams, via thioester formation and in situ azide reduction and cyclisation under high-dilution conditions; since the quantitative conversion of macrolactams to macrolactones has been shown to be feasible, this results in an indirect, alternative macrolactonisation procedure.
Mart� Bartra, Valent� Bou, Jordi Garcia, F�lix Urpi, Jaume Vilarrasa   +4 more
openaire   +1 more source

Macrolactamization of Glycosylated Peptide Thioesters by the Thioesterase Domain of Tyrocidine Synthetase [PDF]

Chemistry and Biology, 2004
The 35 kDa thioesterase (TE) domain excised from the megadalton tyrocidine synthetase (Tyc Syn) retains autonomous capacity to macrocyclize peptidyl thioesters to D-Phe1-L-Leu10-macrolactams. Since a number of nonribosomal peptides undergo O-glycosylation events during tailoring to gain biological activity, the Tyc Syn TE domain was evaluated for ...
Hening Lin, Desirée A Thayer, Chi-Huey Wong   +2 more
exaly   +3 more sources

Macrolactam immunomodulators for topical treatment of inflammatory skin diseases

Journal of the American Academy of Dermatology, 2001
The immunomodulatory macrolactams provide an alternative to glucocorticosteroids for the topical treatment of atopic dermatitis and other inflammatory dermatoses. Tacrolimus (FK506), as well as the newer ascomycin derivative ASM 981 (pimecrolimus), penetrate the inflamed epidermis and are suitable for topical therapy.
E, Bornhövd, W H, Burgdorf, A, Wollenberg   +2 more
openaire   +2 more sources

Recent advance in macrolactams: Structure, bioactivity, and biosynthesis

Bioorganic Chemistry
Macrolactams have garnered significant attention in recent years due to their diverse structures and remarkable biological activities. Despite the increasing number of new members being reported, a systematic discussion of recent advancements in this family is still lacking, particularly in areas such as structure-activity relationship and newly ...
Jiawei, Qiu, Ruochang, Qin, Shuai, Zhi, Liwei, Liu   +3 more
openaire   +2 more sources

ChemInform Abstract: New Bis‐indolic Macrolactams.

ChemInform, 2002
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Jacques Henin, Eric Noe, Jean‐Yves Laronze   +2 more
openaire   +1 more source

First chemoenzymatic synthesis of immunomodulating macrolactam pimecrolimus

Tetrahedron Letters, 2009
The preparation of pimecrolimus, a synthetic derivative of ascomycin endowed with immunomodulatory activity, requires the selective protection of 24-hydroxy group of the ascomycin, before elaboration of the 32-hydroxy group. The aim was achieved by means of two regioselective Candida antarctica lipase-catalyzed steps.
P. Ferraboschi, D. Colombo, M. De Mieri, P. Grisenti   +3 more
openaire   +2 more sources