Results 101 to 110 of about 442 (127)
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Synthesis and Structure of Macrolactams of 3α‐Aminodeoxycholanic Acid
European Journal of Organic Chemistry, 2006AbstractThe macrolactams cyclo(3α‐aminodeoxycholic amide)2 (1) and cyclo(3α‐aminodeoxycholic amide)3 (2) were prepared in high yields (1: 32 %; 2: 41 %) from the pentafluorophenyl esters of the linear precursors. The solid‐state structures of both macrocycles were determined by X‐ray diffraction.
Martin Feigel +4 more
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Biosynthetic pathway of macrolactam polyketide antibiotic cremimycin
Tetrahedron, 2011Abstract Biosynthetic origin of macrolactam polyketide antibiotic cremimycin was investigated by feeding experiments with [1-13C]acetate, [1,2-13C2]acetate, [1-13C]propionate, succinate-d4, and d -[6,6-2H2]glucose. NMR analysis of the resultant isotope-enriched cremimycins showed distinctive incorporation patterns, which suggested that the aglycon ...
Keita Amagai +2 more
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ChemInform Abstract: A Facile and Efficient Method for Macrolactamization.
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
D. BAI, Y. BO, Q. ZHOU
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Efficient Synthesis and Astonishing Supramolecular Architectures of Several Symmetric Macrolactams
Chemistry – A European Journal, 2007AbstractThe synthesis of four Cn symmetric macrocyclic lactams cyclo‐[NH‐CH2‐CHCH‐CH2‐CO]n (1, n=2; 2, n=3; 3, n=4) and cyclo‐[NH‐CH2‐CH2‐CHCH‐CO]3 (4) has been achieved by two approaches. A linear route leads to precursors that are subsequently macrocyclized in a separate step.
Pierre, Baillargeon +4 more
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A new macrolactam derivative from the marine actinomycete HF-11225
The Journal of Antibiotics, 2018A new macrolactam derivative, designated as nivelactam B (1), was isolated from the fermentation broth of marine-derived actinomycete HF-11225. Its structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques, as well as ESI-MS and comparison with data from the literature.
Hua, Chen, Kezhou, Cai, Risheng, Yao
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Mechanisms of β-amino acid incorporation in polyketide macrolactam biosynthesis
Current Opinion in Chemical Biology, 2016Macrolactam antibiotics are an important class of macrocyclic polyketides. In recent years, the number of identified β-amino acid-containing macrolactams and their biosynthetic gene clusters have greatly expanded. Functional analyses of vicenistatin biosynthetic enzymes have revealed conserved biosynthetic machinery that incorporates a β-amino acid ...
Akimasa Miyanaga +2 more
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Polyene Macrolactams from Marine Micromonospora sp.
The Natural Products JournalIntroduction: Three novel macrolactams, FW8-1 (1), FW8-4 (2), and FW60-20 (3), were isolated from a culture of Micromonospora sp. The structures of these compounds were elucidated using Mass Spectrometry (MS) and comprehensive Nuclear Magnetic Resonance (NMR) analyses.
Wei Zhao +10 more
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Recent applications of ring-closing metathesis in the synthesis of lactams and macrolactams
Chemical Communications, 2010Lactams are an important class of compounds owing to their presence in numerous biologically active molecules of natural and unnatural nature. They are also highly versatile intermediates that can be elaborated into interesting compounds for potential use in organic and medicinal chemistry endeavors.
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Structurally Diverse Macrolactams from an Antarctic Streptomyces Species
Journal of Natural ProductsTwelve new polyenic macrolactams, cyclamenols G-R (1 and 3-13), together with the known analogue cyclamenol A (2), were isolated from Streptomyces sp. OUCMDZ-4348. Their structures were elucidated by spectroscopic analysis, quantum chemical calculations, chemical derivatizations, and Mosher's methods.
Jingjing Shen +4 more
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