Results 81 to 90 of about 86,656 (282)

Flow Synthesis of Muscone‐Macrocycles Using the Eschenmoser Rearrangement as a Key Step

Helvetica Chimica Acta, EarlyView.
A two‐step flow process, comprising the formation of hydrazones followed by Eschenmoser fragmentation, enables the efficient synthesis of macrocyclic ketones, which serve as precursors for exaltone and muscone. ABSTRACT Hydrazone formation followed by Eschenmoser fragmentation are key steps in the synthesis of muscone‐type macrocycles.
Merlin Hauer, Oliver Fifield, Florian Fricke, Alexandra Seeman, Ian R. Baxendale, Johannes Panten, Andreas Kirschning   +6 more
wiley   +1 more source

Prevalence and Distribution of Antimicrobial Resistance-Associated Mutations in Mycoplasma genitalium Identified Through Routine Molecular Diagnostics in Korea

Microorganisms
Mycoplasma genitalium is a significant sexually transmitted pathogen, and its clinical management is increasingly complicated by the global distribution of mutations associated with macrolide and fluoroquinolone resistance.
Ho-Jae Lim, Yoon-Taek Hong, Seung-Hui Baek, Min-Young Park, Min-Jin Kim, Yong-Hak Sohn, Yong-Jin Yang   +6 more
doaj   +1 more source

Immunomodulatory Effects of Macrolide Antibiotics - Part 2: Advantages and Disadvantages of Long-Term, Low-Dose Macrolide Therapy

, 2010
The available evidence for long-term, low-dose treatment with 14- and 15-membered ring macrolides in non-cystic fibrosis (CF) bronchiectasis, COPD, chronic sinusitis, and asthma is reviewed with special attention to possible adverse effects and the ...
de Graaff, C. S., Boersma, W. G., J. Altenburg, W.G. Boersma, C.S. de Graaff, van der Werf, T. S., T.S. van der Werf, Altenburg, J.   +7 more
core   +1 more source

Antivirulence activity of azithromycin in Pseudomonas aeruginosa

Frontiers in Microbiology, 2014
Antibiotics represent our bulwark to combat bacterial infections, but the spread of antibiotic resistance compromises their clinical efficacy. Alternatives to conventional antibiotics are urgently needed in order to complement the existing antibacterial ...
Francesco eImperi, Livia eLeoni, Paolo eVisca   +2 more
doaj   +1 more source

Role of macrolide therapy in chronic obstructive pulmonary disease

, 2008
Fernando J Martinez1, Jeffrey L Curtis1,2, Richard Albert31Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI, USA; 2Pulmonary and Critical Care Medicine Section, Ann Arbor VA Health System, Ann Arbor ...
Richard Albert, Jeffrey L Curtis, Fernando J Martinez   +2 more
core  

Increase in Pneumococcus Macrolide Resistance, United States

, 2009
During year 6 (2005–2006) of the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin surveillance study, 6,747 Streptococcus pneumoniae isolates were collected at 119 centers.
David J. Farrell, Stephen G. Jenkins
core   +1 more source

Nutritional and environmental determinants of maturation and disruption of the early life gut microbiome: A narrative review

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract The first 1000 days of life represent a critical window for gut microbiome assembly, with lifelong implications for child growth, immune development, and disease risk. This review synthesizes evidence on maternal, perinatal, and especially nutritional factors that influence early‐life intestinal colonization and highlights the consequences of ...
Carly Burow, Romy Shenderey, Fariha Chowdhury, Nyah Shah, Nikhil Pai   +4 more
wiley   +1 more source

Spread of dual-class drug-resistant Mycoplasma genitalium in Tokyo, Japan, 2023–2025

Antimicrobial Agents and Chemotherapy
The increasing prevalence of Mycoplasma genitalium (MG) strains harboring macrolide and quinolone resistance-associated mutations (MRMs and QRMs, respectively) is a growing global concern.
Ryuha Omachi, Kazuo Imai, Akihiro Sato, Masashi Tanaka, Hitomi Mizushina, Keita Takeuchi, Nobuaki Mori, Takuya Maeda   +7 more
doaj   +1 more source

Novel mechanism responsible for high-level macrolide resistance in Moraxella catarrhalis

, 2018
Ayako Kasai,1 Ayaka Ohta,1 Yuina Maeda,1 Kageto Yamada,2 Kazuyuki Tao,3 Ryoichi Saito1 1Department of Molecular Microbiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan ...
Tao K, Saito R, Maeda Y, Ohta A, Kasai A, Yamada K   +5 more
core  

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source