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Drug Resistance Updates, 1998
The macrolides have evolved through four chemical generations since erythromycin became available for clinical use in 1952. The first generation, the 14-membered ring macrolide erythromycin, induced resistance and was replaced by the second generation 16-membered ring macrolides which did not.
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The macrolides have evolved through four chemical generations since erythromycin became available for clinical use in 1952. The first generation, the 14-membered ring macrolide erythromycin, induced resistance and was replaced by the second generation 16-membered ring macrolides which did not.
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Are Pneumococci Resistant to Macrolides ?
The Egyptian Journal of Medical Microbiology, 2015Background: Streptococcus pneumoniae is the most common cause of acute community-acquired pneumonia and accounts for 30‑40% of lower respiratory tract infections. It accounts also for about 50% of hospital-acquired pneumonia. Macrolides remain the primary antibiotic of choice for physicians treating such infections. Macrolide resistance in Strept.
Michael N. Agban +2 more
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Selection of macrolide‐resistant Campylobacter in pigs treated with macrolides
Veterinary Record, 2014CONTINUOUS use of veterinary antimicrobials can lead to antimicrobial resistance (Asai and others 2005). Macrolides (MLs) such as erythromycin (intramuscular) and tylosin (oral) are administered more frequently in pigs than other food animals (Tamura 2003, MAFF 2012).
M, Usui, I, Uchida, Y, Tamura
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Nihon rinsho. Japanese journal of clinical medicine, 1997
Resistance mechanisms to macrolide antibiotics involving lincosamide and streptogramin type B antibiotics were described in bacteria. Phenotype in the resistant microorganism is generally observed as one of two characteristics, i.e., decrease of intracellular macrolide-accumulation and inactivation of the drugs. The former phenotypic resistance results
K, Endou, Y, Nakajima
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Resistance mechanisms to macrolide antibiotics involving lincosamide and streptogramin type B antibiotics were described in bacteria. Phenotype in the resistant microorganism is generally observed as one of two characteristics, i.e., decrease of intracellular macrolide-accumulation and inactivation of the drugs. The former phenotypic resistance results
K, Endou, Y, Nakajima
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Transferable lincosamide-macrolide resistance in Bacteroides
Plasmid, 1979Abstract Inter- and intraspecies transfer of resistance to clindamycin, lincomycin, and erythromycin in the strict anaerobe, Bacteroides, is described. This lincosamide-macrolide resistance was found to be specified by a 27 × 106-dalton plasmid, designated pBF4, originally identified in a clinical Bacteroides fragilis isolate.
R A, Welch, K R, Jones, F L, Macrina
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Natural and Acquired Macrolide Resistance in Mycobacteria
Current Drug Targets - Infectious Disorders, 2002The genus Mycobacterium contains two of the most important human pathogens, Mycobacterium tuberculosis and Mycobacterium leprae, the etiologic agents of tuberculosis and leprosy, respectively. Other mycobacteria are mostly saprophytic organisms, living in soil and water, but some of them can cause opportunistic infections.
F, Doucet-Populaire +3 more
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Macrolide resistance in Belgian Streptococcus pneumoniae
Journal of Antimicrobial Chemotherapy, 2000The genetic basis of macrolide resistance was characterized in 59 Streptococcus pneumoniae isolates. All isolates were collected in 1995 and 1997 and were from invasive infections. The majority of the isolates (54 of 59 isolates) were erythromycin and clindamycin resistant (MLS(B)-phenotype) and carried the ermAM gene.
K, Lagrou +5 more
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What is the clinical impact of macrolide resistance?
Current Infectious Disease Reports, 2004Respiratory tract infections are treated empirically. Treatment is based on the likely pathogens and their antibiotic susceptibility. The most common respiratory tract pathogen is Streptococcus pneumoniae. In the United States, approximately 25% to 30% of S. pneumoniae are resistant to erythromycin and other macrolides.
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Mobile macrolide resistance genes in staphylococci
Plasmid, 2018Macrolide resistance in staphylococci is based on the expression of a number of genes which specify four major resistance mechanisms: (i) target site modification by methylation of the ribosomal target site in the 23S rRNA, (ii) ribosome protection via ABC-F proteins, (iii) active efflux via Major Facilitator Superfamily (MFS) transporters, and (iv ...
Andrea T, Feßler +3 more
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The role of ribosomal RNAs in macrolide resistance
Molecular Microbiology, 1997Macrolides are bacteriostatic antibiotics which interfere with the peptidyltransfer function of the ribosome. We have investigated the molecular mechanisms underlying macrolide resistance in Mycobacterium smegmatis, an eubacterium carrying two rRNA operons.
P, Sander +4 more
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