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Macrolide Resistance from the Ribosome Perspective
Current Drug Target -Infectious Disorders, 2004Macrolides are important antibiotics used in treatment of respiratory tract infections in humans. Although some of these compounds have been in use for 50 years, it has not been until the last few years that their mechanism of action and the nature of ribosomal-based resistance could be more fully understood.
F, Franceschi +3 more
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Mechanisms of bacterial resistance to macrolide antibiotics
Journal of Infection and Chemotherapy, 1999Macrolides have been used in the treatment of infectious diseases since the late 1950s. Since that time, a finding of antagonistic action between erythromycin and spiramycin in clinical isolates1 led to evidence of the biochemical mechanism and to the current understanding of inducible or constitutive resistance to macrolides mediated by erm genes ...
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Macrolide resistance in Streptococci and Haemophilus influenzae
Clinics in Laboratory Medicine, 2004Antimicrobial resistance is a growing problem among pathogens from respiratory tract infections. b-Lactam resistance rates are escalating among Streptococcus pneumoniae and Haemophilus influenzae. Macrolides are increasingly used for the treatment of respiratory tract infections, but their utility is compromised by intrinsic and acquired resistance ...
Bülent, Bozdogan, Peter C, Appelbaum
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Resistance phenotypes conferred by macrolide phosphotransferases.
FEMS microbiology letters, 2007This study aims to compare the resistance phenotypes conferred by various genes encoding enzymes that phosphorylate erythromycin. The mph genes were cloned into Escherichia coli AG100A susceptible to macrolides and ketolides following disruption of the AcrAB pump.
Chesneau, Olivier +2 more
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Macrolide Resistance in Mycobacteria
Medicinal Chemistry Reviews - Online, 2005Doucet-Populaire, F. +3 more
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Macrolide Resistance in Bordetella pertussis: Current Situation and Future Challenges
Antibiotics, 2022Lauri Ivaska, Qiushui He, Jussi Mertsola
exaly
Resistance toTetracyclines, Macrolides,Trimethoprim, and Sulfonamides
2003Tetracyclines are antimicrobial agents that interact with bacterial ribosomes and block protein synthesis. They have activity against a wide range of gram positive, gram-negative, anaerobic and aerobic bacteria, cell-wall free myco plasmas, chlamydiae, mycobacteria, rickettsia, Helicobacter, Listeria, and protozoan parasites, such as Entamoeba ...
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Macrolide resistance in group A Streptococcus
The Pediatric Infectious Disease Journal, 2002Alexandra F, Freeman +1 more
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