Results 161 to 170 of about 103,280 (234)

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1717-1737, October 2026.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman, Claudio Pedrick, Cara A. Kreck, Ricardo L. Mancera   +3 more
wiley   +1 more source

Engineering macromolecular crowding-driven amyloid-mineral hybrid scaffolds for enhanced bone regeneration. [PDF]

Bioact Mater
Ye Y, Li X, Feng H, Zhang S, Zhou X, Li M, Li F, Zhi C, Chen Z, Zhang X, Fang Z, Fang F, Yang P, Zhang X.   +13 more
europepmc   +1 more source

Local and Large-Scale Conformational Dynamics in Unfolded Proteins and IDPs. I. Effect of Solvent Viscosity and Macromolecular Crowding. [PDF]

J Phys Chem B, 2023
Stecher K, Krieger F, Schleeger M, Kiefhaber T.   +3 more
europepmc   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, Volume 293, Issue 20, Page 6155-6175, October 2026.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Effects of macromolecular crowding on protein folding and aggregation

We have studied the effects of polysaccharide and protein crowding agents on the refolding of oxidized and reduced hen lysozyme in order to test the prediction that association constants of interacting macromolecules in living cells are greatly increased

core  

PEG-mCherry interactions beyond classical macromolecular crowding. [PDF]

Protein Sci
Haas-Neill L, Joron K, Lerner E, Rauscher S.   +3 more
europepmc   +1 more source

Trypanosomal MICOS Is Assembled on Non‐Respiring Mitochondrial Crista Precursors and Associates With Two Integral Microproteins

Molecular Microbiology, Volume 126, Issue 4, Page 396-411, October 2026.
The mitochondrial membrane‐shaping machinery MICOS is assembled surprisingly early during the life cycle of Trypanosoma brucei, before the mitochondrion acquires its mature architecture or full respiratory capacity. Our study also identifies two previously uncharacterized proteins associated with MICOS, providing new insight into the early organization
Michala Boudová, Teresa Wagner, Tomáš Bílý, Martina Tesařová, Corinna Benz, Hassan Hashimi   +5 more
wiley   +1 more source

Fiscal deficit, capital formation, and crowding out: Evidence from India. [PDF]

Theoretical literature identifies two variants of crowding out in an economy-real and financial. The real (direct) crowding out occurs when the increase in public investment displaces private capital formation broadly on a dollar-for-dollar basis ...
Chakraborty, Lekha S.
core  

Insights on the effect of macromolecular crowding on transcription and its regulation. [PDF]

QRB Discov
Xu W, Collette D, Qian J, Finzi L, Dunlap D.   +4 more
europepmc   +1 more source

Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding. [PDF]

Mol Cell, 2022
Sang D, Shu T, Pantoja CF, Ibáñez de Opakua A, Zweckstetter M, Holt LJ.   +5 more
europepmc   +1 more source