Results 91 to 100 of about 2,713 (253)
Mathematical model of a flow of reacting substances in a channel of network [PDF]
arXiv, 2019 Complex systems often have features that can be modeled by advanced mathematical tools [1]. Of special interests are the features of complex systems that have a network structure as such systems are important for modeling technological and social processes [3, 4]. In our previous research we have discussed the flow of a single substance in a channel of
arxiv
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
FoodsExopolysaccharides are natural macromolecular bioactive substances produced by lactic acid bacteria. With their unique physiological activity and structural characteristics, they are gradually showing broad application prospects in the food and ...
Shengnan Liang +3 more
doaj +1 more source
Tunguska similar impacts and origin of life [PDF]
arXiv, 2013 The author suggests new vision of mechanism of initiation of life on the planets after Tunguska similar impacts. This mechanism takes into consideration not only incoming cosmic organic substance but also information, which is connected to this substance.
arxiv
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Model of a motion of substance in a channel of a network consisting of two arms [PDF]
arXiv, 2018 We study the problem of the motion of substance in a channel of a network for the case of channel having two arms. Stationary regime of the flow of the substance is considered. Analytical relationships for the distribution of the substance in the nodes of the arms of the channel are obtained. The obtained results are discussed from the point of view of
arxiv
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen +6 more
wiley +1 more source
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, 2019 Natural flocculants as chitosan and sodium alginate has physic-chemical properties: biodegradability, reaction and complexing ability, compatibility with living tissues without toxicity.
A. F. Tymchuk, K. A. Kvasuk
doaj +1 more source