Results 81 to 90 of about 141,802 (323)

Systems Biology Graphical Notation: Process Diagram Level 1 [PDF]

open access: yes, 2008
Standard graphical representations have played a crucial role in science and engineering throughout the last century. Without electrical symbolism, it is very likely that our industrial society would not have evolved at the same pace.
Anatoly Sorokin   +9 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

microRNA represses macromolecule [PDF]

open access: yesBlood, 2015
In this issue of Blood, Xiang et al identify a novel mechanism, involving activation of the polyol pathway and repression of microRNA-24 (miR-24), through which hyperglycemia augments von Willebrand factor (VWF) expression and secretion.
openaire   +4 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Influence of high molecular elastomers on a turbulent flow of hydrocarbon liquids

open access: yesИзвестия Томского политехнического университета: Инжиниринг георесурсов, 2019
To increase the capacity of pipelines and reduce energy costs for movement of fluid volume unit the traditional ways of reducing viscosity are used. They are heating, dilution and add of low-viscosity solvent depressants.
Vladimir Manzhay   +2 more
doaj   +2 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Construction with macromolecules

open access: yesMaterials Today, 2005
The generation of nanosized features via the bottom-up organization of individual atoms and molecules represents one of the most rapidly emerging fields in modern science and technology. In order to gain general and modular access to nanostructures, a construction kit consisting of molecular building blocks with defined nanoscale dimensions, shape, and
openaire   +2 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Combination of Analytical Pyrolysis and fractionation of technical lignin as a tool for improvement of its antioxidant properties [PDF]

open access: yes, 2012
Antioxidant properties of parent lignin and its fractions was assessed in the tests with free radicals ABTS•+ and DPPH. Increasing ratio between content of syringyl and guaiacyl substructures and the extent of conjugation of lignin macromolecule (Py-GC ...
Arshanitsa, Alexandr   +4 more
core  

On entropy production for controlled Markovian evolution

open access: yes, 2006
We consider thermodynamic systems with finitely many degrees of freedom and subject to an external control action. We derive some basic results on the dependence of the relative entropy production rate on the controlling force.
Pavon, M., Ticozzi, F.
core   +1 more source

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