Results 91 to 100 of about 888,704 (294)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Further development of pulsed ultrafiltration analysis of ligand-macromolecule interactions.
, 1995 Further development of pulsed ultrafiltration analysis of ligand-macromolecule ...
Shen. Chen (7972088)
core
Addition of Macromolecular Marine DOM Cycling to the Marine Biogeochemistry Library (MARBL)
Journal of Advances in Modeling Earth SystemsThe differential cycling of marine macromolecules, such as dissolved carbohydrates, proteins, and lipids play a fundamental role in marine microbial metabolisms, ultimately regulating the ocean's capacity to sequester carbon downwards via the biological ...
Robert T. Letscher, J. Keith Moore
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Efficient γ-aminobutyric acid editing at 3T without macromolecule contamination: MEGA-SPECIAL.
, 2011 One of the most commonly used methods for in vivo MRS detection of γ-aminobutyric acid (GABA) is the MEGA-point-resolved spectroscopy (MEGA-PRESS) technique.
Cowen, Philip +9 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2007 The NIST/NASA/CARB Biological Macromolecule studies requires not only finding suitable chemical agents Crystallization Database (BMCD) contains crystal data that induce and sustain crystal growth but also that those and crystallization conditions for ...
M. Tung, J. E. Ladner, G. L. Gilliland
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Anion Interactions with Macromolecule-Carboxyl-Bound Cations
, 1964 The interaction of anions with cations bound to cation-exchange materials is a little-understood branch of chemistry. The chemistry of such systems is important as a basis for the understanding of many problems in such diverse branches of science as ...
Spedding, D J
core
Zeitschrift für Kristallographie - New Crystal StructuresC48H35Fe2NO4P2Se2, monoclinic, P21/c, a = 20.3289(18) Å, b = 12.6909(11) Å, c = 17.6743(16) Å, β = 109.767(4)∘, V = 4291.1(7) Å3, Z = 4, Rgt(F) = 0.0638, wRref(F2) = 0.1439, T = 298(2) K.
Lü Shuang, Li Qian-Li
doaj +1 more source