Results 111 to 120 of about 888,704 (294)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Ultrasound-mediated intrascleral macromolecule delivery
, 2009 Delivering macromolecules to the posterior segment of eye non-invasively is always challenging as the eye has several barriers to protect it from being invaded. The barriers can be summarized into dynamic, static and metabolic barriers.
Cheung, Chi Yeung
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Process for the preparation of a dendritic macromolecule [PDF]
, 1996 The invention relates to a process for the preparation of a dendritic macromolecule, wherein an amount of a core molecule comprising at least one functional group is dissolved in a solvent, after which alternatingly an addition reaction and a ...
Man, HCJ de +7 more
core +1 more source
Тонкие химические технологии, 2012 The effect of molecular mass on adsorption of epoxy oligomers on water-toluene solution interfaces and a glass dispersed filler surface was investigated.
I. D. Simonov-Emeljanov +4 more
doaj
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Macromolecule Diffusiophoresis Induced by Concentration Gradients of Aqueous Osmolytes
, 2018 Diffusiophoresis is the migration of a particle in a fluid induced by the concentration gradient of another solute. We have experimentally investigated diffusiophoresis of a neutral macromolecule, poly(ethylene glycol) (PEG; molecular weight, 20 kg mol ...
Lara R. Lechlitner +3 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source