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The in silico macrophage: toward a better understanding of inflammatory disease [PDF]
Genome Medicine 2011, 3:4 (22 January 2011), 2011 Macrophages function as sentinel, cell-regulatory hubs capable of initiating, perpetuating and contributing to the resolution of an inflammatory response, following their activation from a resting state. Highly complex and varied gene expression programs within the macrophage enable such functional diversity.
Ghazal, Peter +3 more
arxiv +6 more sources
International Journal of Molecular Sciences, 2022 Immunological memory is a crucial part of the immune defense that allows organisms to respond against previously encountered pathogens or other harmful factors. Immunological memory is based on the establishment of epigenetic modifications of the genome.
Malgorzata Kloc +3 more
openaire +3 more sources
Macrophage depletion disrupts immune balance and energy homeostasis. [PDF]
, 2014 Increased macrophage infiltration in tissues including white adipose tissue and skeletal muscle has been recognized as a pro-inflammatory factor that impairs insulin sensitivity in obesity.
Feng, Gen-Sheng +4 more
core +21 more sources
Liposomal Dexamethasone Reduces A/H1N1 Influenza-Associated Morbidity in Mice
Frontiers in Microbiology, 2022 Re-emerging viral threats have continued to challenge the medical and public health systems. It has become clear that a significant number of severe viral infection cases are due to an overreaction of the immune system, which leads to hyperinflammation ...
Jung Won Kwon +9 more
doaj +1 more source
Microbial Biotechnology, 2022 Summary Colorectal cancer pathogenesis and progression is associated with the presence of Fusobacterium nucleatum and the reduction of acetylated derivatives of spermidine, as well as dietary components such as tannin‐rich foods.
José Miguel Mancheño +23 more
doaj +1 more source
Effects of mesoporous SiO2-CaO nanospheres on the murine peritoneal macrophages -- Candida albicans interface [PDF]
Int Immunopharmacol International Immunopharmacology. 2021 Mar
20;94:107457, 2021 The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects of the drug but, the uptake of these nanocarriers could induce adverse effects on cells and tissues after their incorporation. Macrophages play a central role in host defense and are responsible for in vivo nanoparticle trafficking.
arxiv +1 more source
A new era of macrophage-based cell therapy
Experimental and Molecular Medicine, 2023 Macrophages are essential innate immune cells found throughout the body that have protective and pathogenic functions in many diseases. When activated, macrophages can mediate the phagocytosis of dangerous cells or materials and participate in effective ...
Yi Rang Na +2 more
doaj +1 more source
Macrophage anti-inflammatory behaviour in a multiphase model of atherosclerotic plaque development [PDF]
Bull Math Biol 85, 37 (2023), 2022 Atherosclerosis is an inflammatory disease characterised by the formation of plaques, which are deposits of lipids and cholesterol-laden macrophages that form in the artery wall. The inflammation is often non-resolving, due in large part to changes in normal macrophage anti-inflammatory behaviour that are induced by the toxic plaque microenvironment ...
arxiv +1 more source
Journal of Nanobiotechnology, 2023 Background Immune checkpoint inhibitors such as anti-programmed cell death protein 1 (PD1) block tumor growth by reinvigorating the immune system; however, determining their efficacy only by the changes in tumor size may prove inaccurate.
Gyo Jeong Gu +7 more
doaj +1 more source
Immunity, 2014 Macrophages are a diverse population of phagocytic cells that reside in tissues throughout the body. At sites of infection, macrophages encounter and engulf invading microbes. Accordingly, macrophages possess specialized effector functions to kill or coordinate the elimination of their prey.
Jordan V. Price, Russell E. Vance
openaire +3 more sources