Results 11 to 20 of about 793,649 (316)

Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development

open access: yesCells, 2020
Vaccine design traditionally focuses on inducing adaptive immune responses against a sole target pathogen. Considering that many microbes evade innate immune mechanisms to initiate infection, and in light of the discovery of epigenetically mediated ...
Samuel T. Pasco, Juan Anguita
doaj   +1 more source

A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity

open access: yesScientific Reports, 2021
While the dire cardiometabolic consequences of the hypercaloric modern ‘Western’ diet are well known, there is not much information on the health impact of a high sucrose diet not inducing weight gain. Here, we tested the hypothesis that rats reared with
Omkar L. Patkar   +16 more
doaj   +1 more source

Susceptibility to Infections During Acute Liver Injury Depends on Transient Disruption of Liver Macrophage Niche

open access: yesFrontiers in Immunology, 2022
Kupffer cells are the primary liver resident immune cell responsible for the liver firewall function, including clearance of bacterial infection from the circulation, as they are strategically positioned inside the liver sinusoid with intimate contact ...
Mateus Eustáquio Lopes   +10 more
doaj   +1 more source

Segmentation based tracking of cells in 2D+time microscopy images of macrophages [PDF]

open access: yes, 2023
The automated segmentation and tracking of macrophages during their migration are challenging tasks due to their dynamically changing shapes and motions. This paper proposes a new algorithm to achieve automatic cell tracking in time-lapse microscopy macrophage data.
arxiv   +1 more source

A Catalogus Immune Muris of the mouse immune responses to diverse pathogens

open access: yesCell Death and Disease, 2021
Immunomodulation strategies are crucial for several biomedical applications. However, the immune system is highly heterogeneous and its functional responses to infections remains elusive. Indeed, the characterization of immune response particularities to
Céline Barlier   +7 more
doaj   +1 more source

Leukocyte-Specific Morrbid Promotes Leukocyte Differentiation and Atherogenesis

open access: yesResearch, 2023
Monocyte-to-M0/M1 macrophage differentiation with unclear molecular mechanisms is a pivotal cellular event in many cardiovascular diseases including atherosclerosis.
Di Xiang   +22 more
doaj   +1 more source

Ratio of CD68/CD163 in Breast Carcinoma with and without Axillary Lymph Node Metastatic

open access: yesFolia Medica Indonesiana, 2021
Tumor and its microenvironment can interact each other. Macrophage is part of tumor microenvironment. New drugs targeting specific superficial receptor of macrophage or cytokine of macrophage polarization have been found.
Priangga Adi Wiratama, Willy Sandhika
doaj   +1 more source

Identification of a highly active tannase enzyme from the oral pathogen Fusobacterium nucleatum subsp. polymorphum

open access: yesMicrobial Cell Factories, 2018
Background Tannases are tannin-degrading enzymes that have been described in fungi and bacteria as an adaptative mechanism to overcome the stress conditions associated with the presence of these phenolic compounds.
Julen Tomás-Cortázar   +10 more
doaj   +1 more source

Macrophage migration inhibitory factor in acute kidneyinjury

open access: yesFrontiers in Physiology, 2022
Acute kidney injury (AKI) is a complex clinical syndrome with multiple etiologies and pathogenesis, which lacks early biomarkers and targeted therapy.
Yiwei Du, Hao Hao, Heng Ma, Hongbao Liu
doaj   +1 more source

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. [PDF]

open access: yes, 2018
Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in glioblastoma (GBM).
Brem, Steven   +17 more
core   +3 more sources

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