Results 11 to 20 of about 1,549,373 (292)

The M1 and M2 paradigm of macrophage activation: time for reassessment

F1000Prime Reports, 2014
Macrophages are endowed with a variety of receptors for lineage-determining growth factors, T helper (Th) cell cytokines, and B cell, host, and microbial products.
F. Martínez, S. Gordon
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Macrophage Polarization States in the Tumor Microenvironment

International Journal of Molecular Sciences, 2021
The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, commonly deemed tumor-associated macrophages (TAMs), are contributors to many pro-tumorigenic ...
Ava J Boutilier, Sherine F. Elsawa
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Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

Nature Immunology, 2018
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific subgroups in supporting fibrogenesis has not been investigated in ...
Dvir Aran, Agnieszka P. Looney, Leqian Liu, Esther Wu, Valerie Fong, Austin Hsu, S. Chak, Ram P. Naikawadi, Paul J. Wolters, A. Abate, A. Butte, M. Bhattacharya   +11 more
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Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

Science immunology, 2022
Description High-dimensional analysis reveals three macrophage subsets with common transcriptional and biological properties across organs. Mapping macrophage heterogeneity Tissue resident macrophages have specific roles in homeostasis, inflammation, and
Sarah A. Dick, Anthony Wong, Homaira Hamidzada, S. Nejat, Robert Nechanitzky, S. Vohra, Brigitte Mueller, Rysa Zaman, Crystal Kantores, Laura Aronoff, A. Momen, Duygu Nechanitzky, Wanda Y. Li, Parameswaran Ramachandran, S. Q. Crome, B. Becher, M. Cybulsky, F. Billia, S. Keshavjee, S. Mital, Clint S. Robbins, T. Mak, S. Epelman   +22 more
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Diversity, Mechanisms, and Significance of Macrophage Plasticity.

Annual Review of Pathology, 2020
Macrophages are a diverse set of cells present in all body compartments. This diversity is imprinted by their ontogenetic origin (embryonal versus adult bone marrow-derived cells); the organ context; the activation or deactivation of various signals in ...
M. Locati, G. Curtale, A. Mantovani
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Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

Nature Communications, 2021
Macrophages perform diverse functions within tissues during immune responses to pathogens and injury, but molecular mechanisms by which physical properties of the tissue regulate macrophage behavior are less well understood.
Hamza Atcha, Amit Jairaman, Jesse R. Holt, V. Meli, Raji R. Nagalla, P. K. Veerasubramanian, Kyle T. Brumm, Huy E Lim, Shivashankar Othy, M. Cahalan, Medha M. Pathak, Wendy F. Liu   +11 more
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Metabolic reprogramming in macrophage responses

Biomarker Research, 2021
Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment ...
Yang Liu, Ruyi Xu, Huiyao Gu, E. Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He, Z. Cai   +9 more
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Macrophage Polarization and Its Role in Liver Disease

Frontiers in Immunology, 2021
Macrophages are important immune cells in innate immunity, and have remarkable heterogeneity and polarization. Under pathological conditions, in addition to the resident macrophages, other macrophages are also recruited to the diseased tissues, and ...
Cheng Wang, Cheng Ma, Lihong Gong, Yuqin Guo, K. Fu, Yafang Zhang, Honglin Zhou, Yunxia Li   +7 more
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Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Critical Care, 2021
Polymorphonuclear neutrophils (PMNs) play an important role in sepsis-related acute lung injury (ALI). Accumulating evidence suggests PMN-derived exosomes as a new subcellular entity acting as a fundamental link between PMN-driven inflammation and tissue
Yang Jiao, Ti Zhang, Chengmi Zhang, Haiying Ji, Xingyu Tong, Ran Xia, Wei Wang, Zhengliang Ma, Xueyin Shi   +8 more
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Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

Nature Reviews Cardiology, 2021
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis and contribute to the development of novel diagnostic and therapeutic strategies to further reduce the risk of cardiovascular disease.
Wei Chen, M. Schilperoort, Yihai Cao, Jinjun Shi, I. Tabas, Wei Tao   +5 more
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