Results 61 to 70 of about 746,406 (260)

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]

, 2011
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Francis, S. E., Calogero Tulone, Read, R. C., Sheila E. Francis, Mitchell, T.J., Read Robert C., Benny Chain, Marriott, Helen M, Deretic, V., Dockrell, David H, Marriott, H.M., Francis, Sheila E, Dockrell, David H., Whyte, M.K.B., Martin A. Bewley, Mitchell Timothy J., Timothy J Mitchell, Whyte, Moira K B, Kroemer, G., Chain, B., Moira K. B. Whyte, Helen M Marriott, Sheila E Francis, Tulone Calogero, Robert C Read, Bewley, M.A., Dockrell, D.H., Whyte Moira K. B., Whyte, Moira K. B., Marriott Helen M., Read, Robert C., Marriott, H. M., Chain, Benny, Tulone, C., Read, R.C., Mitchell, Timothy J., Whyte, Moira K.B., David H. Dockrell, Mitchell, Timothy J, Francis Sheila E., David H Dockrell, Kroemer, Guido, Moira K B Whyte, Marriott, Helen M., Chain Benny, Mitchell, T. J., Timothy J. Mitchell, Bewley, Martin A, Dockrell, D. H., Read, Robert C, Tulone, Calogero, Francis, S.E., Robert C. Read, Dockrell David H., Bewley, Martin A., Martin A Bewley, Helen M. Marriott, Bewley, M. A., Dockrell, David, Bewley Martin A., Whyte, M. K. B., Guido Kroemer, Francis, Sheila E., Kroemer Guido   +63 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Gut microbiota and immunometabolism in obesity

Gut Microbes
The gut microbiota plays a central role in modulating both immunity and metabolism. Obesity-associated microbiota configuration is a critical driver of persistent inflammatory activation and immune dysfunction, ultimately leading to chronic metabolic ...
Alba Torres-Mayo, Rebeca Liébana-García, Marta Olivares, Aize Pellón, Juan Anguita, Yolanda Sanz   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

alexcoulton/macrophage-atlas: Macrophage Atlas

<p>Macrophage atlas code version 1</p ...
apodeme
core   +1 more source

Macrophage-Mediated Porous Magnetic Nanoparticles for Multimodal Imaging and Postoperative Photothermal Therapy of Gliomas

, 2021
Because of the blood–brain barrier and the high infiltration of glioma cells, the diagnostic accuracy and treatment efficiency of gliomas are still facing challenges.
Liang Cheng (228343), Lingli Zeng (152769), Yue Pan (267516), Ziying Chen (4904428), Qing Tao (651802), Chunhong Hu (105578), Hailin Shen (2405716), Hui Dai (198810), Yunjiao Zhang (662638), Guotao Yuan (6052595), Jingzhong Zhang (411984), Sheng Wang (339979), Qiulian Mao (8791388), Yonggang Li (300645)   +13 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Macrophage-derived exosomes regulate gastric cancer cell oxaliplatin resistance by wrapping circ 0008253

, 2022
Oxaliplatin (OXA) is a first-line chemotherapy drug for gastric cancer. We aimed to investigate the effect of circ 0008253, contained in M2 polarized macrophage-derived exosomes, on OXA resistance of gastric carcinoma cells.
Dandan Yu (162326), Zhiwei Chang (11446523), Xiaolei Liu (104141), Huixian Zhang (619360), Pengfei Chen (462170), Yanru Qin (290764)   +5 more
core   +1 more source

The significance of M1/M2 macrophage-like monocytes in children with systemic lupus erythematosus

European Journal of Inflammation, 2019
Monocytes/macrophages are important in the development of systemic lupus erythematosus. To research M1 and M2 macrophage-like monocytes in the peripheral blood of children with systemic lupus erythematosus and explore the clinical significance, M1 and M2
Xiao-Ling Niu, Dan Feng, Sheng Hao, Xin-Yu Kuang, Ying Wu, Guang-Hua Zhu, Wen-Yan Huang   +6 more
doaj   +1 more source