Results 71 to 80 of about 567,704 (267)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

CXCL8 mediates macrophage migration in canine oral malignant melanoma

Scientific Reports
Tumor-associated macrophage (TAM) infiltration is associated with poor prognosis in human patients with melanoma. However, the mechanism by which TAMs infiltrate tumor tissues in dogs remains unclear.
Nao Okauchi, Shusaku Shibutani, Masashi Sakurai, Hiroka Yamamoto, Kazuhito Itamoto, Daiki Kato, Takayuki Nakagawa, Sadatoshi Maeda, Kenji Baba, Takuya Mizuno, Masaya Igase   +10 more
doaj   +1 more source

Del-1 nanoparticles/silk fibroin hydrogel accelerates the healing of chronic skin wounds by promoting inflammation regression

陆军军医大学学报
Objective To investigate the effect of silk fibroin hydrogel loaded with developmental endothelial locus-1 (Del-1) nanoparticles on the healing of chronic skin wounds in mice.
KAN Xuewei, YAO Pingping, CHEN Jiaqi
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Loss of LpqM proteins in Mycobacterium abscessus is associated with impaired intramacrophage survival

Microbiology Spectrum
Mycobacterium abscessus, an emerging pathogen responsible for severe pulmonary infections in cystic fibrosis patients, displays either a smooth (S) or a rough (R) morphotype. Infections with M.
Yves-Marie Boudehen, Wassim Daher, Françoise Roquet-Baneres, Laurent Kremer   +3 more
doaj   +1 more source

A macrophage is a macrophage is a macrophage—in metastasis

Oncotarget, 2023
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Disulfiram, an Anti-alcoholic Drug, Targets Macrophages and Attenuates Acute Rejection in Rat Lung Allografts

Transplant International
Macrophages contribute to post-transplant lung rejection. Disulfiram (DSF), an anti-alcoholic drug, has an anti-inflammatory effect and regulates macrophage chemotactic activity. Here, we investigated DSF efficacy in suppressing acute rejection post-lung
Nobuyuki Yoshiyasu, Rei Matsuki, Masaaki Sato, Hirokazu Urushiyama, Etsuko Toda, Etsuko Toda, Yasuhiro Terasaki, Yasuhiro Terasaki, Masaki Suzuki, Aya Shinozaki-Ushiku, Yuya Terashima, Jun Nakajima   +11 more
doaj   +1 more source