Results 71 to 80 of about 793,649 (316)

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

Cell Reports, 2020
Summary: Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play a major role in inflammation, we studied the contribution of Mfn2 to the ...
Juan Tur, Selma Pereira-Lopes, Tania Vico, Eros A. Marín, Juan P. Muñoz, Maribel Hernández-Alvarez, Pere-Joan Cardona, Antonio Zorzano, Jorge Lloberas, Antonio Celada   +9 more
doaj  

Nocardia rubra cell‐wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells

Cancer Medicine, 2022
Background As an immune enhancer, Nocardia rubra cell‐wall skeleton (Nr‐CWS) has been used to treat persistent human papillomavirus infection and cervical precancerous lesions.
Siyang Zhang, Han Wang, Yisi Liu, Tao Tao, Zhi Zeng, Yingying Zhou, Min Wang   +6 more
doaj   +1 more source

Ginsenoside Rb2 Alleviated Atherosclerosis by Inhibiting M1 Macrophages Polarization Induced by MicroRNA-216a

Frontiers in Pharmacology, 2022
Introduction: Atherosclerosis is a chronic disease characterized by the inflammatory process and lipid depositions. We previously reported that microRNA-216a (miR-216a) can accelerate the progression of atherosclerosis by promoting the polarization of M1
Shuting Wang, Shujun Yang, Shujun Yang, Yu Chen, Yutong Chen, Rongxia Li, Shuang Han, Adalaiti Kamili, Yiyi Wu, Weili Zhang   +9 more
doaj   +1 more source

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. [PDF]

, 2014
The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of ...
Bandyopadhyay, Gautam, Bogner-Strauss, Juliane G, Chi, Tyler J, Chung, Heekyung, Evans, Ronald M, Franck, Niclas, Hah, Nasun, Heinrichsdorff, Jan, Mayoral, Rafael, Morinaga, Hidetaka, Oh, Da Young, Olefsky, Jerrold M, Osborn, Olivia, Pessentheiner, Ariane R, Walenta, Evelyn   +14 more
core   +2 more sources

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Origins and diversity of macrophages in health and disease

Clinical & Translational Immunology, 2020
Macrophages are the first immune cells in the developing embryo and have a central role in organ development, homeostasis, immunity and repair. Over the last century, our understanding of these cells has evolved from being thought of as simple phagocytic
Gopalkrishna Sreejit, Andrew J Fleetwood, Andrew J Murphy, Prabhakara R Nagareddy   +3 more
doaj   +1 more source

The double-edged sword effect of macrophage targeting delivery system in different macrophage subsets related diseases

Journal of Nanobiotechnology, 2020
Background Monocyte/macrophage-targeting delivery systems (MTDSs) have been focused upon as an emerging routine for delivering drugs to treat various macrophage-related diseases.
Yuchuan Yuan, Ling Long, Jiaxing Liu, Yongyao Lin, Cuiping Peng, Yue Tang, Xuemei Zhou, Shuhui Li, Chengyuan Zhang, Xiaohui Li, Xing Zhou   +10 more
doaj   +1 more source

Activation of LXR Nuclear Receptors Impairs the Anti-Inflammatory Gene and Functional Profile of M-CSF-Dependent Human Monocyte-Derived Macrophages

Frontiers in Immunology, 2022
Liver X Receptors (LXR) control cholesterol metabolism and exert anti-inflammatory actions but their contribution to human macrophage polarization remains unclear.
Arturo González de la Aleja, Cristina Herrero, Mónica Torres-Torresano, Juan Vladimir de la Rosa, Bárbara Alonso, Enrique Capa-Sardón, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kröger, Miguel A. Vega, Antonio Castrillo, Antonio Castrillo, Ángel L. Corbí   +12 more
doaj   +1 more source

Mouse hepatitis virus neurovirulence: evidence of a linkage between S glycoprotein expression and immunopathology. [PDF]

, 2004
Differences in disease outcome between the highly neurovirulent MHV-JHM and mildly neurovirulent MHV-A59 have been attributed to variations within the spike (S) glycoprotein.
An, Askovic, Basler, Baudoux, Buchmeier, Castro, Drescher, Fazakerley, Fleming, Fleming, Haring, Haring, Ito, Jeffrey Meisner, Julia D. Rempel, Kubo, Lane, Lavi, Luo, Marten, Michael J. Buchmeier, Parker, Perlman, Phillips, Rempel, Schijns, Shannon J. Murray, Song, Stalder, Stohlman, Taguchi, Talbot, Talbot, Wege, Wu, Xiong, Yee, Zhang   +37 more
core   +1 more source