Results 71 to 80 of about 546,176 (246)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Research progress on the interaction between glucose metabolic reprogramming and lactylation in tumors

Frontiers in Immunology
Glucose metabolic reprogramming describes the alterations in intracellular metabolic pathways in response to variations in the body’s internal environment. This metabolic reprogramming has been the subject of extensive research.
Yi Yang, Yi Yang, Yi Wu, Yi Wu, Hui Chen, Hui Chen, Zehai Xu, Zehai Xu, Ruisi Lu, Ruisi Lu, Sijie Zhang, Sijie Zhang, Rui Zhan, Rui Zhan, Qinghua Xi, Qinghua Xi, Yunfeng Jin, Yunfeng Jin   +17 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Bioinformatics analysis to investigate the potential relationship between mitochondrial structure and function-related genes and the immune microenvironment in atherosclerosis

Frontiers in Cardiovascular Medicine
ObjectiveThis study aims to elucidate the interactions between genes associated with mitochondrial structure and function and the immune microenvironment in atherosclerosis.MethodsDifferentially expressed mitochondria-related genes (DE-MRGs) were ...
Hanning Yang, Yue Sun, Shumin Li, Yueyue Tang, Yuxue Wang, Yunyan Li, Yongping Lu   +6 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Endoneurial immune interplay in peripheral nerve repair: insights and implications for future therapeutic interventions

Frontiers in Neuroscience
The mechanisms underlying axonal injury and repair in peripheral nerves, whether due to traumatic damage or autoimmune neuropathies, are complex and not yet fully understood.
Alina Sprenger-Svačina, Alina Sprenger-Svačina, Martin K. R. Svačina, Martin K. R. Svačina, Husniye G. Otlu, Husniye G. Otlu, Tong Gao, Kazim A. Sheikh, Gang Zhang   +8 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Corrigendum: Susceptibility to infections during acute liver injury depends on transient disruption of liver macrophage niche

Frontiers in Immunology, 2022
Mateus Eustáquio Lopes, Brenda Naemi Nakagaki, Matheus Silvério Mattos, Gabriel Henrique Campolina-Silva, Gabriel Henrique Campolina-Silva, Raquel de Oliveira Meira, Pierre Henrique de Menezes Paixão, André Gustavo Oliveira, Lucas D. Faustino, Ricardo Gonçalves, Gustavo Batista Menezes   +10 more
doaj   +1 more source

Near-infrared fluorescent nanoprobe enables noninvasive, longitudinal monitoring of graft outcome in RPE transplantation

Frontiers in Medicine
ObjectivesRetinal pigment epithelium (RPE) cell transplantation holds therapeutic promise for retinal degenerative diseases, but longitudinal monitoring of graft survival and efficacy remains clinically challenging.
Guanzhou Di, Chen Lu, Mengting Xue, Limin Zheng, Limin Zheng, Weiqi Li, Runmin Xie, Xinpei Yuan, Xu Zhen, Min Wu, Xiying Mao, Songtao Yuan   +11 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source