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Macrophage Activation Syndrome [PDF]
Macrophage activation syndrome (MAS) is a potentially life-threatening complication of rheumatic disorders that occurs most commonly in systemic juvenile idiopathic arthritis.
Alberto Martini +2 more
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MACROPHAGE ACTIVATION SYNDROME
Journal of Clinical Gastroenterology, 2011We recently treated a patient with adult-onset Still's disease who developed macrophage activation syndrome (MAS) secondary to disseminated histoplasmosis while being treated with adalimumab. The gastroenterology service was consulted early, before diagnosis, as the patient presented with elevated liver enzymes and disseminated intravascular ...
Bijal A, Jayakar, Philip J, Hashkes
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Macrophage Activation Syndrome
Arthritis & RheumatologyMacrophage activation syndrome (MAS) is a state of immune hyperactivation that can result in life‐threatening multisystem end‐organ dysfunction. Often termed a “cytokine storm,” MAS occurs among the rheumatic diseases most typically in Still's disease but also in systemic lupus erythematosus and Kawasaki disease.
Sean Deane, M. Eric Gershwin
+6 more sources
The genetics of macrophage activation syndrome
Genes & Immunity, 2020Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis (HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and high mortality rates. Laboratory and clinical features resemble primary HLH, which arises in infancy (1 in 50,000 live births) from homozygous mutations in various genes critical to
Grant S, Schulert, Randy Q, Cron
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