Results 51 to 60 of about 6,205,257 (290)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Expression and function of macrophage migration inhibitory factor (MIF) in melioidosis. [PDF]

PLoS Neglected Tropical Diseases, 2010
Macrophage migration inhibitory factor (MIF) has emerged as a pivotal mediator of innate immunity and has been shown to be an important effector molecule in severe sepsis.
W Joost Wiersinga, Thierry Calandra, Liesbeth M Kager, Gerritje J W van der Windt, Thierry Roger, Didier le Roy, Sandrine Florquin, Sharon J Peacock, Fred C G J Sweep, Tom van der Poll   +9 more
doaj   +1 more source

Does Macrophage Migration Inhibitory Factor predict the prognosis of COVID-19 disease?

Journal of Infection in Developing Countries, 2021
Introduction: The aim of this study is to investigate whether macrophage migration inhibitory factor (MIF) predicts the prognosis of COVID-19 disease.
Hamad Dheir, Selcuk Yaylaci, Savas Sipahi, Ahmed Cihad Genc, Deniz Cekic, Fatma Betul Tuncer, Erdem Cokluk, Havva Kocayigit, Ahmed Bilal Genc, Salih Salihi, Ceyhun Varim, Oguz Karabay   +11 more
doaj   +1 more source

Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation. [PDF]

, 2009
Contains fulltext : 80470.pdf (Publisher’s version ) (Open Access)The cytokine macrophage migration inhibitory factor plays a central role in inflammation, cell proliferation and tumorigenesis.
Roger, T., Sweep, F.C., Ding, X.C., Chanson, Anne-Laure, Calandra, Thierry, Le Roy, D., Le Roy, Didier, Calandra, T, Lugrin, J., Sweep, Fred C.G.J., Calandra, T., Chanson, A.L., Lugrin, Jérôme, Roger, Thierry, Sweep, C.G.J., Ding, Xavier C., Roy, D. Le   +16 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Benzisothiazolones as modulators of macrophage migration inhibitory factor [PDF]

Bioorganic & Medicinal Chemistry Letters, 2011
Substituted N-phenylbenzisothiazolones have been investigated as inhibitors of the tautomerase activity of the proinflammatory cytokine MIF (macrophage migration inhibitory factor). Numerous compounds were found to possess antagonist activity in the low micromolar range with the most potent being the 6-hydroxy analog 1w.
William L, Jorgensen, Alexander, Trofimov, Xin, Du, Alissa A, Hare, Lin, Leng, Richard, Bucala   +5 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury

Cell Death and Disease, 2022
Ischemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a promising target for neuroprotection in many neurological disorders, including ischemic stroke.
Jin-Xia Hu, Wei-Jing Ma, Li-Ying He, Cong-Hui Zhang, Cheng Zhang, Yan Wang, Chao-Nan Chen, Da-Yong Shen, Hui-Min Gao, Rui-Ru Guo, Qian-Qian Ning, Xin-Chun Ye, Gui-Yun Cui, Lei Li   +13 more
doaj   +1 more source

Macrophage migration inhibitory factor, infection, the brain, and corticosteroids [PDF]

, 2009
Bacterial meningitis is a complex disorder in which injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response.
Geldhoff, Madelijn, Mook-Kanamori, B.B., Geldhoff, M., van de Beek, D., Mook-Kanamori, Barry B., van de Beek, Diederik   +5 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source