Results 91 to 100 of about 166,541 (336)

Role of Macrophages in Cardiac Remodeling: Cues From Zebrafish Heart

Immunity, Inflammation and Disease
Background Macrophages are a key component of innate immunity and regulate cardiac phenotypes by their polarization state. The classical M1 macrophages are activated by pro‐inflammatory stimuli, whereas M2 macrophages are activated by anti‐inflammatory ...
Himanshu Gaur, Maram Hasan, Huseyin C. Yalcin   +2 more
doaj   +1 more source

Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

Nature Communications, 2019
Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.
Tao Yu, Shucheng Gan, Qingchen Zhu, Dongfang Dai, Ni Li, Hui Wang, Xiaosong Chen, Dan Hou, Yan Wang, Qiang Pan, Jing Xu, Xingli Zhang, Junli Liu, Siyu Pei, Chao Peng, Ping Wu, Simona Romano, Chaoming Mao, Mingzhu Huang, Xiaodong Zhu, Kunwei Shen, Jun Qin, Yichuan Xiao   +22 more
doaj   +1 more source

Heparinization of beta tricalcium phosphate: osteo-immunomodulatory effects [PDF]

, 2018
"This is the pre-peer reviewed version of the following article: A. Diez-Escudero, M. Espanol, M. Bonany, X. Lu, C. Persson, M.-P. Ginebra, Adv. Healthcare Mater.
Bonany Mariñosa, Mar, Díez Escudero, Anna, Español Pons, Montserrat, Ginebra Molins, Maria Pau, Persson, Cecilia   +4 more
core   +2 more sources

S100A9 Regulated M1/M2 Macrophage Polarization in Interleukin-10- induced Promotion of Malignant Pleural Effusion [PDF]

, 2023
Xue‐Bin Pei, Feng‐Shuang Yi, Shu‐Feng Dong, Qingyu Chen, Xinyu Shi   +4 more
openalex   +1 more source

Phenotypic Polarization of Macrophages in Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
Macrophages orchestrate the inflammatory response in inflamed tissues, and recent work indicates that these cells can alter their phenotypes and functions accordingly in response to changes in the microenvironment. Initial work in models of cardiovascular disease used immunologic markers to characterize macrophage phenotypes present in atherosclerotic ...
Norbert, Leitinger, Ira G, Schulman
openaire   +2 more sources

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

PGC-1α inhibits M2 macrophage polarization and alleviates liver fibrosis following hepatic ischemia reperfusion injury

Cell Death Discovery, 2023
Oxidative stress can induce inflammation, promoting macrophage polarization and liver fibrosis following hepatic ischemia-reperfusion (I/R). Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has anti-oxidant and anti-inflammatory ...
Yanting Zhang, Linzhong Zhang, Yanmian Zhao, Jing He, Yanghao Zhang, Xiuying Zhang   +5 more
doaj   +1 more source

MicroRNA let-7c Regulates Macrophage Polarization [PDF]

The Journal of Immunology, 2013
Abstract Macrophages demonstrate a high level of plasticity, with the ability to undergo dynamic transition between M1 and M2 polarized phenotypes. The role of microRNAs (miRNAs) in regulating macrophage polarization has been largely undefined.
Sami, Banerjee, Na, Xie, Huachun, Cui, Zheng, Tan, Shanzhong, Yang, Mert, Icyuz, Edward, Abraham, Gang, Liu   +7 more
openaire   +2 more sources

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Periodontal ligament cells-derived exosomes promote osteoclast differentiation via modulating macrophage polarization

Scientific Reports
Several studies have demonstrated that exosomes (Exos) are involved in the regulation of macrophage polarization and osteoclast differentiation. However, the characteristics as well as roles of exosomes from human periodontal ligament cells (hPDLCs-Exos)
Xinyi Bai, Yingxue Wang, Xinyuan Ma, Yingying Yang, Cong Deng, Mengling Sun, Chen Lin, Linkun Zhang   +7 more
doaj   +1 more source