Results 111 to 120 of about 166,541 (336)

Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis

Cell Death and Disease
Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction.
Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu   +6 more
doaj   +1 more source

Biointerface Membranes Orchestrating Site‐Specific Osteoimmunomodulatory and Antibacterial Effects for Enhanced Osseous Regeneration in Periodontal Therapy

Advanced Functional Materials, EarlyView.
Here, a biointerface membrane engineered with site‐specific interfacial properties is developed. During implantation between gingival and bone defect, the membrane creates a pro‐osteogenic microenvironment, precisely modulates cellular activities at each biointerface, and facilitates the orchestration of complex healing events, ultimately leading to ...
Yuwei Zhu, Tingting Wang, Jing Zhu, Bingtian Zhao, Bingyang Dai, Xiaoyue Zhang, Wei Liu, Cheng Yang, Cheng Dong, Ren Liu, Lei Zhao, Jun Wang, Peilei Shi, To Ngai   +13 more
wiley   +1 more source

Brain macrophages in human cortical contusions as indicator of survival period [PDF]

, 1986
The aim of this study was to establish a morphologic time scheme with which cases of cerebral contusion with unknown survival periods can be dated. Our study of 275 cases was limited to qualitative and quantitative changes in macrophages.
Adams, Adams, Adrian, Baggenstoss, Carmichael, Clopper, del Rio-Hortega, Edelmann, Eisenmenger, Gedigk, Gedigk, Gerhard Berghaus, Gerhard Raff, Hallermann, Hammes, Howarth, Jacob, Kennady, Konigsmark, Krauland, Környey, Link, Manfred Oehmichen, Meesen, Müller, Oehmichen, Oehmichen, Oehmichen, Oehmichen, Russell, Sachs, Schröder, Schröder, Schröder, Spielmeyer, Strassmann, Wolfgang Eisenmenger   +36 more
core   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization

Frontiers in Immunology
Macrophages polarized into distinct phenotypes play vital roles in inflammatory diseases by clearing pathogens, promoting tissue repair, and maintaining homeostasis.
Yina An, Shuyu Tan, Jingjing Yang, Ting Gao, Yanjun Dong   +4 more
doaj   +1 more source

A 3-D in vitro co-culture model of mammary gland involution. [PDF]

, 2014
Involution is a process whereby the mammary gland undergoes extensive tissue remodelling involving exquisitely coordinated cell death, extracellular matrix degradation and adipose tissue regeneration following the weaning of offspring.
Botos, Laur-Alexandru, Cameron, Ruth E., Campbell, Jonathan J., Davidenko, Natalia, Sargeant, Timothy J., Watson, Christine J.   +5 more
core   +3 more sources

4D‐Printable Poly(Thio)urethane Photoresins With Reactive Oxygen Species Responsiveness and Anti‐Inflammatory Functionality

Advanced Functional Materials, EarlyView.
This work introduces UV‐curable poly(thio)urethane (PSU) thermosets as 4D printable scaffolds responsive to oxidative stress. PSU networks with 100 wt.% polypropylene glycol (PPG) effectively suppress inflammatory markers in microglial cells to basal values.
Xabier Lopez de Pariza, Lolita Arévalo‐Lagos, Louise Breloy, Oihane Varela, Aitor Larrañaga, Juan F. Cadavid‐Vargas, Olaia Garagarza‐Goienetxea, Melissa Moya‐Granados, Vanessa Bagnarello, Haritz Sardon, Miryam Criado‐Gonzalez   +10 more
wiley   +1 more source

Treatment of silicosis with quercetin depolarizing macrophages via inhibition of mitochondrial damage-associated pyroptosis

Ecotoxicology and Environmental Safety
Macrophage polarization facilitates the inflammatory response and intensified fibrosis in the silicosis microenvironment by a mechanism related to macrophage pyroptosis, although the upstream target remains poorly defined.
Chuan-Yong Xiao, Yijun Tang, Tao Ren, Cunqing Kong, Hui You, Xiao-Feng Bai, Qi Huang, Yi Chen, Liu-Gen Li, Mei-Yi Liu, Fan Leng, Ning Han, Tong-Fei Li, Mei-Fang Wang   +13 more
doaj   +1 more source

In vivo metabolic imaging of Traumatic Brain Injury. [PDF]

, 2017
Complex alterations in cerebral energetic metabolism arise after traumatic brain injury (TBI). To date, methods allowing for metabolic evaluation are highly invasive, limiting our understanding of metabolic impairments associated with TBI pathogenesis ...
Chaumeil, Myriam M, Chou, Austin, Feng, Xi, Guglielmetti, Caroline, Krukowski, Karen, Najac, Chloe, Riparip, Lara-Kirstie, Rosi, Susanna   +7 more
core   +2 more sources

Macrophage Polarization and Infection

Journal of Bacteriology and Virology, 2014
Monocytes and macrophages regulate host immune system against infectious pathogens. Activated macrophages play an important role in restricting the multiplication and dissemination of pathogens. The concept of alternative activation of macrophages might provide useful insights into pathology of infectious diseases. M1 macrophages (classically activated
Yun-Ji Lim, Chang-Hwa Song
openaire   +1 more source