Results 191 to 200 of about 139,946 (311)

Macrophage differentiation and polarization on a decellularized pericardial biomaterial [PDF]

, 2010
Marianne B. Ariganello, Dan Simionescu, Rosalind S. Labow, J. Michael Lee   +3 more
openalex   +1 more source

On a Stochastic PDE Model for Epigenetic Dynamics [PDF]

arXiv
We propose and analyze a stochastic model to investigate epigenetic mutations, i.e., modifications of the genetic information that control gene expression patterns in a cell but do not alter the DNA sequence. Epigenetic mutations are related to environmental fluctuations, which leads us to consider (additive) noise as the driving element for such ...
arxiv  

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Advanced Age Impairs Macrophage Polarization [PDF]

, 2011
Shegufta Mahbub, Cory Deburghgraeve, Elizabeth J. Kovacs   +2 more
openalex   +1 more source

Extracellular vesicle-packaged miR-4253 secreted by cancer-associated fibroblasts facilitates cell proliferation in gastric cancer by inducing macrophage M2 polarization

Cancer Biology & Therapy
Cancer-associated fibroblasts (CAFs) can interact with macrophages in the tumor microenvironment by secreting extracellular vesicles (EVs), thereby affecting tumor progression. However, the mechanisms of CAF-secreted EVs in gastric cancer (GC) remain not
Xinxing Duan, Xiong Yu, Jin Gan
doaj   +1 more source

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source

Effect of Cytokine Interplay on Macrophage Polarization during Chronic Pulmonary Infection with Cryptococcus neoformans [PDF]

, 2011
Shikha Arora, Michal A. Olszewski, Tiffany Tsang, Roderick A. McDonald, Galen B. Toews, Gary B. Huffnagle   +5 more
openalex   +1 more source

Treatment of silicosis with quercetin depolarizing macrophages via inhibition of mitochondrial damage-associated pyroptosis

Ecotoxicology and Environmental Safety
Macrophage polarization facilitates the inflammatory response and intensified fibrosis in the silicosis microenvironment by a mechanism related to macrophage pyroptosis, although the upstream target remains poorly defined.
Chuan-Yong Xiao, Yijun Tang, Tao Ren, Cunqing Kong, Hui You, Xiao-Feng Bai, Qi Huang, Yi Chen, Liu-Gen Li, Mei-Yi Liu, Fan Leng, Ning Han, Tong-Fei Li, Mei-Fang Wang   +13 more
doaj  

Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential

Frontiers in Pharmacology
Resveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties.
Panting Wang, Panting Wang, Zixi Li, Yixuan Song, Bowei Zhang, Chaofeng Fan, Chaofeng Fan   +6 more
doaj   +1 more source

Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury

Advanced Science, EarlyView.
Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang, Zeli Xiang, Pengfei Yang, Ling Zhang, Jun Deng, Xiaohui Liao   +5 more
wiley   +1 more source