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Advanced Science, EarlyView.CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin +17 more
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Macrophage Polarization in Atherosclerosis
Genes, 2022 The implication of the heterogeneous spectrum of pro- and anti-inflammatory macrophages (Macs) has been an important area of investigation over the last decade. The polarization of Macs alters their functional phenotype in response to their surrounding microenvironment.
Arul Jayaraman +2 more
exaly +3 more sources
Macrophage Polarization and Osteoporosis: A Review [PDF]
Nutrients, 2020 Over 200 million people suffer from osteoporosis worldwide. Individuals with osteoporosis have increased rates of bone resorption while simultaneously having impaired osteogenesis. Most current treatments for osteoporosis focus on anti-resorptive methods to prevent further bone loss.
Bahram Arjmandi +2 more
exaly +3 more sources
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Annual Review of Physiology, 2017
Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and the normal tissue environment.
exaly +3 more sources
Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and the normal tissue environment.
exaly +3 more sources
Macrophage Polarization States in the Tumor Microenvironment
International Journal of Molecular Sciences, 2021 The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, commonly deemed tumor-associated macrophages (TAMs), are contributors to many pro-tumorigenic ...
Sherine Elsawa, Ava Boutilier
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Macrophage polarization in atherosclerosis
Clinica Chimica Acta, 2020Atherosclerosis is a chronic inflammatory response that increases the risk of cardiovascular diseases. An in-depth study of the pathogenesis of atherosclerosis is critical for the treatment of atherosclerotic cardiovascular disease. The development of atherosclerosis involves many cells, such as endothelial cells, vascular smooth muscle cells ...
Lushan Liu, Zhong Ren, Zhihan Tang
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Implications of macrophage polarization in autoimmunity [PDF]
Immunology, 2018 SummaryMacrophages are extremely heterogeneous and plastic cells with an important role not only in physiological conditions, but also during inflammation (both for initiation and resolution). In the early 1990s, two different phenotypes of macrophages were described: one of them called classically activated (or inflammatory) macrophages (M1) and the ...
Mariana Rios, Alexis Kalergis
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Macrophage polarization in pathology
Cellular and Molecular Life Sciences, 2015Macrophages are cells of the innate immunity constituting the mononuclear phagocyte system and endowed with remarkable different roles essential for defense mechanisms, development of tissues, and homeostasis. They derive from hematopoietic precursors and since the early steps of fetal life populate peripheral tissues, a process continuing throughout ...
SICA, Antonio +3 more
openaire +3 more sources
Macrophage activation and polarization
Frontiers in Bioscience, 2008Macrophages are widely distributed immune system cells that play an indispensable role in homeostasis and defense. They can be phenotypically polarized by the microenvironment to mount specific functional programs. Polarized macrophages can be broadly classified in two main groups: classically activated macrophages (or M1), whose prototypical ...
Martinez FO +3 more
openaire +5 more sources
Polarized Activation of Macrophages
2014Macrophages are mononuclear phagocytes which play important roles in many aspects of immunity, tissue repair and metabolism. Plasticity is a key feature of these cells and consists in the capability to modulate their phenotypic and functional aspects under distinct stimuli derived from the microenvironment. A number of transcription factors, epigenetic
Galdiero, M. R. +2 more
openaire +2 more sources