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Serine metabolism in macrophage polarization
Inflammation Research, 2023Emerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of serine for their activation and functionalization, necessitating our insight into how serine availability and utilization impact macrophage activation and inflammatory responses.This article summarizes the reports published ...
Xinqiong, Huang +3 more
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European Journal of Pharmacology, 2020
Macrophages can be affected by a variety of factors to change their phenotype and thus affect their function. Activated macrophages are usually divided into two categories, M1-like macrophages and M2-like macrophages. Both M1 macrophages and M2 macrophages are closely related to inflammatory responses, among which M1 macrophages are mainly involved in ...
Chen, Yunna +3 more
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Macrophages can be affected by a variety of factors to change their phenotype and thus affect their function. Activated macrophages are usually divided into two categories, M1-like macrophages and M2-like macrophages. Both M1 macrophages and M2 macrophages are closely related to inflammatory responses, among which M1 macrophages are mainly involved in ...
Chen, Yunna +3 more
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Macrophage polarization and bacterial infections
Current Opinion in Infectious Diseases, 2011Macrophages are the first line of defense against pathogens, and the mode of their activation will determine the success or failure of the host response to pathogen aggression. Based on limited numbers of markers, activated macrophages can be classified as classically activated (M1) macrophages that support microbicidal activity or alternatively ...
Jean-Louis, Mège +2 more
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Macrophage polarization in tumour progression
Seminars in Cancer Biology, 2008Macrophages are a fundamental part of the innate defense mechanisms, which can promote specific immunity by inducing T cell recruitment and activation. Despite this, their presence within the tumour microenvironment has been associated with enhanced tumour progression and shown to promote cancer cell growth and spread, angiogenesis and ...
SICA, Antonio +9 more
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Trends in Immunology, 2002
Mononuclear phagocytes are versatile cells that can express different functional programs in response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states.
Alberto Mantovani +2 more
exaly +6 more sources
Mononuclear phagocytes are versatile cells that can express different functional programs in response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states.
Alberto Mantovani +2 more
exaly +6 more sources
Macrophage polarity in cancer: A review
Journal of Cellular Biochemistry, 2018AbstractMacrophages are the most abundant cells within the tumor stroma displaying noticeable plasticity, which allows them to perform several functions within the tumor microenvironment. Tumor‐associated macrophages commonly refer to an alternative M2 phenotype, exhibiting anti‐inflammatory and pro‐tumoral effects.
Masoud Najafi +11 more
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The response of macrophages to titanium particles is determined by macrophage polarization
Acta Biomaterialia, 2013Aseptic loosening of total joint replacements is driven by the reaction of macrophages to foreign body particles released from the implant. It was hypothesized that the macrophages' response to these particles is dependent, in addition to particle characteristics and contaminating biomolecules, on the state of macrophage polarization as determined by ...
Mandelin Jami +7 more
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Modulating macrophage polarization by photobiomodulation
Lasers in Medical SciencePhotobiomodulation (PBM), employing low-power lasers and light-emitting diodes (LEDs), has emerged as an innovative therapeutic modality for modulating macrophage polarization. In this review, we summarized the involvement of PBM in macrophage polarization and described the light physical parameters involved with polarization, focusing on its ability ...
Victoria Batista, Ferreira +2 more
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Macrophage polarization in adenomyosis: A review
American Journal of Reproductive ImmunologyAbstractAdenomyosis (AM) is a common gynecological disorder characterized by the presence of endometrial glands and stroma within the uterine myometrium. It is associated with abnormal uterine bleeding (AUB), dysmenorrhea, and infertility. Although several mechanisms have been proposed to elucidate AM, the exact cause and development of the condition ...
Yingying Qiu +5 more
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Macrophage Polarization and Osteoclast Differentiation
Macrophages are a key player to regulate rheumatoid arthritis pathogenesis from onset to remission. They can alter innate functions under microenvironmental conditions. To understand heterogeneous functions of macrophages in rheumatoid arthritis, several activated statuses of macrophages should be mimicked in vitro.Noritaka, Saeki, Akihiro, Nakata
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