Results 281 to 290 of about 166,541 (336)

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Progress in Research on Macrophage Polarization Mechanisms and Targeted Therapies in <i>Staphylococcus aureus</i> Infections. [PDF]

Infect Drug Resist
Yan W, Li X, Xu S, Pan H, Wang B, Zeng Z, Shi Y.   +6 more
europepmc   +1 more source

Thermogenic Adipocytes Promote M2 Macrophage Polarization through CNNM4‐Mediated Mg Secretion [PDF]

Anke Zhang, Junkun Jiang, Chuan Zhang, Houshi Xu, Wenjing Yu, Zhen‐Ning Zhang, Ling Yuan, Zibin Lu, Yuqing Deng, Haonan Fan, Chaoyou Fang, Xiaoyu Wang, Anwen Shao, Sheng Chen, Huaming Li, Jiahua Ni, Wenhui Wang, Xiaonong Zhang, Jianmin Zhang, Bing Luan   +19 more
openalex   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

TMT1A inhibits lung adenocarcinoma progression by suppressing M2 macrophage polarization. [PDF]

iScience
Pan J, Wu Q, Zhao Y, Wu S, He L, Pan Q, Chen X, Zhang J, Xu Y.   +8 more
europepmc   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Microvesicles from Turmeric Extracts Contain Curcuminoids and Modulate Macrophage Polarization and Migration. [PDF]

Pharmaceutics
Tacconi S, Jalabert A, Berger E, Cotte C, Errazuriz-Cerda E, Bardot V, Leblanc A, Berthomier L, Dubourdeaux M, Rome S.   +9 more
europepmc   +1 more source

Porphyromonas gingivalis GroEL Accelerates Abdominal Aortic Aneurysm Formation by Induction of M1 Polarization in Macrophages [PDF]

Yi Lin, Yi‐Ting Tsai, Ming‐Jen Cheng, Chun Ming Shih, Chun‐Yao Huang, Chien‐Sung Tsai, Shih-Ying Sung, Ze‐Hao Lai, Chen‐Wei Liu, Feng‐Yen Lin   +9 more
openalex   +1 more source

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source

Distinct matrix viscoelasticity in bone fracture hematoma steers macrophage polarization

Knecht RS, Morgan DM, Kollert MR, Noom A, Bucher CH, Mooney DJ, Schmidt-Bleek K, Duda GN.   +7 more
europepmc   +1 more source