Results 221 to 230 of about 261,309 (244)

IL-33-Driven Macrophage Reprogramming as a Potential Immunometabolic Strategy for Herpes Simplex Keratitis. [PDF]

Pharmaceuticals (Basel)
He Y, Liu Y, Ouyang J, Wang C, Liu J, Wu C, Tan Q, Jiang J, Hu K.   +8 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Local M1 Macrophage Reprogramming with Gluconic Acid-Coated Selenium Nanoparticles. [PDF]

Int J Nanomedicine
Liao ZX, Ou DL, Hsu CL, Lu LN, Wen CH, Lu L, Chiu CL, Yang PC, Tseng SJ.   +8 more
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Therapeutic potential of low-dose rosiglitazone in periodontitis: attenuation of inflammation and bone loss through macrophage reprogramming. [PDF]

BMC Oral Health
Zhou LN, Zhang Z, Wang ZT.
europepmc   +1 more source

Targeted silencing of CLYBL with platelet-mimetic siRNA nanoparticles drives itaconate-mediated macrophage reprogramming and protects against sepsis-triggered lung cell death. [PDF]

Cell Death Discov
Huang Z, Zhong J, Zhang L, Huang X, Liang S, Zhu Y, Zhang R, He H, Xu C, Chen W, Wang J, Wu X, Liang Y, Zou J, Zhang S.   +14 more
europepmc   +1 more source

Fmoc-DDT@Fos hydrogel mitigates temporomandibular joint osteoarthritis through regulating macrophage reprogramming and ferroptosis. [PDF]

Mater Today Bio
Zhang Y, Zhang D, Yue X, Xu Q, Bu L, Lu J, Yang C, Shen P, Zheng J.   +8 more
europepmc   +1 more source

Photoactivated <i>Hypericum perforatum</i>-Derived Exosome Nanovesicles Suppress Breast Cancer via miR-172f/CD24-Siglec-G/10-Driven Macrophage Reprogramming. [PDF]

Biomater Res
Zeng P, Lei J, Lu Y, Zhang W, You J, Zheng Y, Wu J.   +6 more
europepmc   +1 more source

Melanoma stem cells drive macrophage reprogramming to a hybrid phenotype, modulating melanoma stemness and compromising NK cell-mediated immunity. [PDF]

Front Immunol
Anselmi M, Francesconi M, Triulzi T, Bernardo G, Le Noci V, Bianchi F, Castagnoli L, Arnaboldi F, Gagliano N, Pupa SM, Limonta P, Sfondrini L, Sommariva M.   +12 more
europepmc   +1 more source

Smart ROS-regulating biomimetic hydrogel promotes scarless diabetic wound healing via macrophage reprogramming. [PDF]

Mater Today Bio
Du P, Li J, Pu J, Dou S, Zhang G, Wu K, Deng S, Wang Q, Liu W.   +8 more
europepmc   +1 more source