Results 91 to 100 of about 1,971,731 (404)

Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model. [PDF]

, 2020
Molecules from animal venoms are promising candidates for the development of new drugs. Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer (PnV) is a potential source of antineoplastic components with activity in ...
Barreto, Natália, Bonfanti, Amanda Pires, Brunetto, Sérgio, Caballero, Marcus, Cordeiro, Gabriel, Moura, Fernanda, Munhoz, Jaqueline, Ramos, Celso Dario, Rapôso, Catarina, Rocha-E-Silva, Thomaz, Sutti, Rafael, Thome, Rodolfo, Verinaud, Liana   +12 more
core   +1 more source

Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy. [PDF]

, 2017
Anti-angiogenic therapies for cancer such as VEGF neutralizing antibody bevacizumab have limited durability. While mechanisms of resistance remain undefined, it is likely that acquired resistance to anti-angiogenic therapy will involve alterations of the
Aghi, MK, Castro, BA, Chen, W, De Lay, M, Flanigan, P, Hoffman, D, Jahangiri, A, Kohanbash, G, Kuang, R, Mascharak, S, Okada, H, Shrivastav, S, Sidorov, M, Wagner, JR, Yagnik, G   +14 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Comprehensive Integration of Single-Cell Transcriptional Profiling Reveals the Heterogeneities of Non-cardiomyocytes in Healthy and Ischemic Hearts

Frontiers in Cardiovascular Medicine, 2020
Advances in single-cell RNA sequencing (scRNA-seq) technology have recently shed light on the molecular mechanisms of the spatial and temporal changes of thousands of cells simultaneously under homeostatic and ischemic conditions.
Lingfang Zhuang, Lingfang Zhuang, Lin Lu, Lin Lu, Ruiyan Zhang, Ruiyan Zhang, Kang Chen, Kang Chen, Xiaoxiang Yan, Xiaoxiang Yan   +9 more
doaj   +1 more source

Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages. [PDF]

, 2019
Many bacterial pathogens hijack macrophages to egress from the port of entry to the lymphatic drainage and/or bloodstream, causing dissemination of life-threatening infections. However, the underlying mechanisms are not well understood.
Ferreira, Fernando, Guo, Betty P, Lebrilla, Carlito B, Lokken, Kristen L, Luxardi, Guillaume, Ma, Li, Maverakis, Emanual, Mogilner, Alex, Reid, Brian, Ryzhuk, Volodymyr, Sun, Yaohui, Sun, Yuxin, Xu, Gege, Zhao, Min, Zhu, Kan   +14 more
core   +2 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Macrophages in Marseille [PDF]

Immunity, 2013
Immunology has recently witnessed several new developments in understanding the biology of macrophages. These exciting developments were the focus of a conference in Marseille, France, in January 2013. This conference is summarized here.
openaire   +2 more sources

Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2)* [PDF]

, 2016
Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways.
Ashley, Jason W, Bone, Robert N, Hancock, William D, Nelson, Alexander J, Ramanadham, Sasanka, Tse, Hubert M, Turk, John, Wohltmann, Mary   +7 more
core   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]

, 2010
Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M., Hamann, Jörg, Hoek, Robert M., Huitinga, Inge, Koning, Nathalie, Pouwels, Walter, Raes, Geert, van Eijk, Marco, Voehringer, David   +8 more
core   +1 more source