Results 61 to 70 of about 1,818,468 (377)

Placental Macrophages Following Maternal SARS-CoV-2 Infection in Relation to Placental Pathology

Frontiers in Virology, 2022
IntroductionIn December 2019, a novel coronavirus, SARS-CoV-2, was identified. Whilst pregnant women appear to be at risk of severe infection, pre-term birth, and stillbirth, it is unclear whether placental dysfunction is a consistent feature of maternal
Megan C. Sharps, Ainslie Garrod, Emmanuel Aneni, Carolyn J. P. Jones, Gauri Batra, Alexander E. P. Heazell, Alexander E. P. Heazell   +6 more
doaj   +1 more source

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

Journal of Immunology, 1992
During normal tissue remodeling, macrophages remove unwanted cells, including those that have undergone programmed cell death, or apoptosis. This widespread process extends to the deletion of thymocytes (negative selection), in which cells expressing ...
V. Fadok, D. Voelker, P. Campbell, J. Cohen, D. Bratton, P. Henson   +5 more
semanticscholar   +1 more source

Tumor-associated macrophages: Oblivious confederates in invasive mammary carcinoma

Asian Journal of Oncology, 2017
Background: The infiltrating margins of carcinomas are associated with presence of inflammatory cell infiltrate which are an integral part of the tumor microenvironment.
Imtiaz Ahmed, Manoj Gopal Madakshira, Puja Dudeja, Reena Bharadwaj   +3 more
doaj   +1 more source

BAFF Blockade Attenuates DSS-Induced Chronic Colitis via Inhibiting NLRP3 Inflammasome and NF-κB Activation

Frontiers in Immunology, 2022
BackgroundBAFF production is increased in IBD patients. However, the specific role of BAFF in IBD is still uncovered. This study aimed to investigate the expression and function of BAFF in experimental colitis and the potential mechanisms.MethodsBAFF ...
Ying Zhang, Meihui Tao, Chaoyue Chen, Xi Zhao, Qinyu Feng, Guang Chen, Yu Fu   +6 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Development of Monocytes, Macrophages, and Dendritic Cells

Science, 2010
Development of Myeloid Immune Cells As leukocytes develop to maturity, they proceed through an array of phenotypically distinct intermediates. For T and B lymphocyte populations, the different developmental stages, anatomical locations, and cell signals ...
F. Geissmann, M. Manz, Steffen Jung, M. Sieweke, M. Merad, K. Ley   +5 more
semanticscholar   +1 more source

Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS

Frontiers in Immunology, 2018
Beta-defensins 2 and 3 (BD2 and BD3) are inducible peptides present at the sites of infection, and they are well characterized for their antimicrobial activities and immune-regulatory functions.
Yongjian Wu, Yongjian Wu, Dandan Li, Dandan Li, Yi Wang, Yi Wang, Xi Liu, Yuanqing Zhang, Wenting Qu, Wenting Qu, Kang Chen, Ngiambudulu M. Francisco, Ngiambudulu M. Francisco, Lianqiang Feng, Lianqiang Feng, Xi Huang, Xi Huang, Xi Huang, Minhao Wu, Minhao Wu   +19 more
doaj   +1 more source

Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis

Frontiers in Immunology, 2020
Endothelial cell dysfunction contributes to sepsis induced initiate immune response and the infiltration of immune cells into organs, resulting in organ injury. Heat shock protein A12B (HSPA12B) is predominantly expressed in endothelial cells.
Fei Tu, Fei Tu, Xiaohui Wang, Xiaohui Wang, Xia Zhang, Xia Zhang, Tuanzhu Ha, Tuanzhu Ha, Yana Wang, Min Fan, Min Fan, Kun Yang, P. Spencer Gill, P. Spencer Gill, Tammy R. Ozment, Tammy R. Ozment, Yuan Dai, Li Liu, David L. Williams, David L. Williams, Chuanfu Li, Chuanfu Li   +21 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source