Results 71 to 80 of about 1,971,731 (404)

Macrophages in obesity

Cellular Immunology, 2018
Obesity is a worldwide public health concern yet no safe therapies are currently available. The activity of sympathetic neurons is necessary and sufficient for fat mass reduction, via norepinephrine (NE) signaling. Macrophage accumulation in the adipose tissue is thought to play the central role in the onset of obesity, yet their relation to NE has ...
Ana Domingos, Ana Domingos, Ana Domingos, Roksana M. Pirzgalska   +3 more
openaire   +2 more sources

PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity

Nature, 2017
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is upregulated on activated T cells for the induction of immune tolerance.
S. Gordon, R. Maute, Ben W. Dulken, G. Hutter, B. George, Melissa N. Mccracken, Rohit Gupta, Jonathan M. Tsai, Rahul Sinha, Daniel M. Corey, A. Ring, A. Connolly, I. Weissman   +12 more
semanticscholar   +1 more source

Germination of Aspergillus fumigatus inside avian respiratory macrophages is associated with cytotoxicity [PDF]

, 2012
Although aspergillosis is one of the most common diseases in captive birds, the pathogenesis of avian aspergillosis is poorly known. We studied the role of avian respiratory macrophages as a first line of defense against avian aspergillosis.
D'Herde, Katharina, Ducatelle, Richard, Favoreel, Herman, Haesebrouck, Freddy, Li, Shaoji, Martel, An, Pasmans, Frank, Van Waeyenberghe, Lieven   +7 more
core   +2 more sources

Safflower Polysaccharide Inhibits AOM/DSS-Induced Mice Colorectal Cancer Through the Regulation of Macrophage Polarization

Frontiers in Pharmacology, 2021
Safflower polysaccharide (SPS) is one of the active fractions extracted from safflower petals (Carthamus tinctorius L.) which has been reported to possess antitumor and immune control roles.
Qun Wang, Yun Huang, Min Jia, Dong Lu, Hong-Wei Zhang, Dan Huang, San-Hong Liu, Chao Lv   +7 more
doaj   +1 more source

Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. [PDF]

, 2012
Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause is the failure of an adequate acute inflammatory response as a result of impaired secretion of pro-inflammatory cytokines by ...
Bielawski, J, Bloom, SL, Goss, V, Han, X, Hannun, YA, Koster, G, Postle, AD, Rahman, FZ, Segal, AW, Sewell, GW, Smith, PJ, Vega, R, Walker, AP   +12 more
core   +1 more source

Silver Nanoparticles as Chlorhexidine and Metronidazole Drug Delivery Platforms: Their Potential Use in Treating Periodontitis

International Journal of Nanomedicine, 2022
Karol P Steckiewicz,1 Piotr Cieciórski,2 Ewelina Barcińska,1 Maciej Jaśkiewicz,3 Magdalena Narajczyk,4 Marta Bauer,3 Wojciech Kamysz,3 Elżbieta Megiel,2 Iwona Inkielewicz-Stepniak1 1Department of Pharmaceutical Pathophysiology, Faculty
Steckiewicz KP, Cieciórski P, Barcińska E, Jaśkiewicz M, Narajczyk M, Bauer M, Kamysz W, Megiel E, Inkielewicz-Stepniak I   +8 more
doaj  

Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNF and IFN [PDF]

, 2014
In cutaneous leishmaniasis, Leishmania amazonensis activates macrophage double-stranded, RNA-activated protein kinase R (PKR) to promote parasite growth. In our study, Leishmania major grew normally in RAW cells, RAW-expressing dominant-negative PKR (PKR-
Abu-Dayyeh I., Aislan de Carvalho Vivarini, Ana Paula C. A. Lima, Da Silva R., Danelli M. G., Jeremy C. Mottram, Marilia S. Faria, Nylen S., Tereza C. Calegari‐Silva, Ulisses Gazos Lopes, Vivarini Ade C.   +10 more
core   +1 more source

Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype

Frontiers in Immunology, 2021
Idiopathic pulmonary fibrosis (IPF) is the most severe form of chronic lung fibrosis. Circulating monocytes have been implicated in immune pathology in IPF but their phenotype is unknown.
Emily Fraser, Laura Denney, Agne Antanaviciute, Karl Blirando, Chaitanya Vuppusetty, Yuejuan Zheng, Yuejuan Zheng, Emmanouela Repapi, Valentina Iotchkova, Stephen Taylor, Neil Ashley, Victoria St Noble, Rachel Benamore, Rachel Hoyles, Colin Clelland, Joseph M. D. Rastrick, Clare S. Hardman, Nasullah K. Alham, Rachel E. Rigby, Alison Simmons, Jan Rehwinkel, Ling-Pei Ho, Ling-Pei Ho   +22 more
doaj   +1 more source

Macrophages and neurodegeneration

Brain Research Reviews, 2005
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Demyelination is a classical feature of MS lesions, and neurological deficits are often ascribed to the reduced signal conduction by demyelinated axons. However, recent studies emphasize that axonal loss is an important factor in MS pathogenesis
Hendriks, Jerome J A, Teunissen, Charlotte E, de Vries, Helga E, Dijkstra, Christine D   +3 more
openaire   +4 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source