Results 71 to 80 of about 1,818,468 (377)

Germination of Aspergillus fumigatus inside avian respiratory macrophages is associated with cytotoxicity [PDF]

, 2012
Although aspergillosis is one of the most common diseases in captive birds, the pathogenesis of avian aspergillosis is poorly known. We studied the role of avian respiratory macrophages as a first line of defense against avian aspergillosis.
D'Herde, Katharina, Ducatelle, Richard, Favoreel, Herman, Haesebrouck, Freddy, Li, Shaoji, Martel, An, Pasmans, Frank, Van Waeyenberghe, Lieven   +7 more
core   +2 more sources

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. [PDF]

, 2012
Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause is the failure of an adequate acute inflammatory response as a result of impaired secretion of pro-inflammatory cytokines by ...
Bielawski, J, Bloom, SL, Goss, V, Han, X, Hannun, YA, Koster, G, Postle, AD, Rahman, FZ, Segal, AW, Sewell, GW, Smith, PJ, Vega, R, Walker, AP   +12 more
core   +1 more source

Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome

Fujita Medical Journal, 2018
Objective: We previously reported that macrophages contribute to the pathogenesis of refractory nephrotic syndrome (NS). To elucidate the mechanism behind macrophage accumulation and to identify a predictive biomarker of steroid responsiveness, we ...
Yuji Matsumoto, Yohei Ikezumi, Tomomi Kondo, Yoko Nakajima, Yasuto Yamamoto, Masashi Morooka, Satoru Kisohara, Tetsuya Ito, Tetsushi Yoshikawa   +8 more
doaj   +1 more source

Chronic kidney disease mediates cardiac dysfunction associated with increased resident cardiac macrophages

BMC Nephrology, 2022
Background The leading cause of death in end-stage kidney disease is related to cardiovascular disease. Macrophages are known to be involved in both chronic kidney disease (CKD) and heart failure, however their role in the development of cardiorenal ...
M. A. Mawhin, R. G. Bright, J. D. Fourre, E. I. Vloumidi, J. Tomlinson, A. Sardini, C. D. Pusey, K. J. Woollard   +7 more
doaj   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System

Frontiers in Immunology, 2018
Since the seminal discovery of dendritic cells (DCs) by Steinman and Cohn in 1973, there has been an ongoing debate to what extent macrophages and DCs are related and perform different functions.
Joanna Grabowska, Miguel A. Lopez-Venegas, Alsya J. Affandi, Joke M. M. den Haan   +3 more
doaj   +1 more source

Silk Particle Production Based on Silk/PVA Phase Separation Using a Microfabricated Co-flow Device

Molecules, 2020
Polymeric particles are ideal drug delivery systems due to their cellular uptake-relevant size. Microparticles could be developed for direct injection of drug formulations into a diseased site, such as a tumor, allowing for drug retention and slow drug ...
Natalia Vargas Montoya, Rachel Peterson, Kimberly J. Ornell, Dirk R. Albrecht, Jeannine M. Coburn   +4 more
doaj   +1 more source

Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice

Frontiers in Immunology, 2021
Neutrophil cytosolic factor 1 (Ncf1) is a major genetic factor associated with autoimmune diseases and has been identified as a key player in autoimmune mediated inflammation.
Mengyao Li, Wentao Zhang, Jing Zhang, Xiaowei Li, Fujun Zhang, Fujun Zhang, Wenhua Zhu, Wenhua Zhu, Liesu Meng, Liesu Meng, Rikard Holmdahl, Rikard Holmdahl, Shemin Lu, Shemin Lu   +13 more
doaj   +1 more source