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Determination of prolactin: The macroprolactin problem
Best Practice and Research in Clinical Endocrinology and Metabolism, 2013Serum prolactin is frequently measured when investigating patients with reproductive disorders and elevated concentrations are found in up to 17% of such cases. Clinical laboratories rely predominantly on automated analysers to quantify prolactin levels using sandwich immunometric methodologies.
Michael Fahie-Wilson, Thomas P Smith
exaly +3 more sources
Macroprolactin: From laboratory to clinical practice.
Endocrinología Diabetes y Nutrición, 2021 Prolactin measurement is very common in standard clinical practice. It is indicated not only in the study of pituitary adenomas, but also when there are problems with fertility, decreased libido, or menstrual disorders, among other problems.
B. Biagetti +14 more
semanticscholar +2 more sources
Evaluation of the analytic performance and macroprolactin sensitivity of a new prolactin immunoassay
Annales D'EndocrinologiePURPOSE Prolactin measurement is essential in endocrine diagnostics. Challenges such as the hook effect and reactivity to macroprolactin, which varies according to the reagent, complicate accurate measurement. The present study evaluated a newly marketed
Pauline Perrin +2 more
exaly +2 more sources
IgA-type macroprolactin among 130 patients with macroprolactinemia
Clinical Chemistry and Laboratory Medicine (CCLM)Objectives Macroprolactin (macro-PRL) mostly comprises a complex of PRL with IgG. The aim of this study was to clarify whether IgA-type macro-PRL exists and, if so, to elucidate the prevalence of and differences in laboratory data from IgG-type.
Masayuki Ishihara +5 more
semanticscholar +3 more sources
Macroprolactin in mothers and their babies: what is its origin?
Clinical Chemistry and Laboratory Medicine (CCLM)Objectives Macroprolactinemia is one of the major causes of hyperprolactinemia. The aim of this study was to clarify the origin of macroprolactin (macro-PRL).
Norito Nishiyama +4 more
semanticscholar +3 more sources
Prolactinomas and macroprolactin: the complexity of interpreting macroprolactin data
Endocrine AbstractsSjana Kos, J. Assmann
semanticscholar +2 more sources
Experimental and Clinical Endocrinology and Diabetes, 2012 Introduction: Prolactin circulates predominantly as a 23-kDa monomer, and a high-molecular-weight form largely consisting of a complex of prolactin and an anti-prolactin IgG autoantibody, called macroprolactin.
Adrian H Heald, Simon G Anderson
exaly +2 more sources
Clinica chimica acta; international journal of clinical chemistry, 2023
BACKGROUND Macroprolactinemia is a common cause of hyperprolactinemia (HPRL), with an average worldwide incidence of 18.9 %. This study aimed to explore the feasibility of ultrafiltration (UF) and polyethylene glycol (PEG) precipitation for ...
X. Ke +8 more
semanticscholar +1 more source
BACKGROUND Macroprolactinemia is a common cause of hyperprolactinemia (HPRL), with an average worldwide incidence of 18.9 %. This study aimed to explore the feasibility of ultrafiltration (UF) and polyethylene glycol (PEG) precipitation for ...
X. Ke +8 more
semanticscholar +1 more source
8 Suspected presence of macroprolactin in the plasma of horses and ponies
Journal of Equine Veterinary Science, 2021N. Galinelli +5 more
semanticscholar +2 more sources