Results 171 to 180 of about 990 (199)

Circulating macroprolactin exhibits molecular heterogeneity and is not exclusively an antibody complex.

Clinica chimica acta; international journal of clinical chemistry, 2020
BACKGROUND Macroprolactin (macPRL) is considered to be solely a prolactin antibody complex. We examined macPRL heterogeneity in samples from thirteen patients suspected of macroprolactinemia.
Khanh Quynh N Nguyen, Rachel H Langevin, Michael J McPhaul, I. Hashim   +3 more
semanticscholar   +1 more source

Hyperprolactinemia Due to Macroprolactin

The Endocrinologist, 2008
Abstract: Macroprolactin is a frequently unrecognized phenomenon giving rise to inaccurate diagnosis in an estimated 10% of cases of hyperprolactinemia in the United States. This has been associated with unnecessary investigation and inappropriate treatment including pituitary exploration.
T Joseph McKenna, Thomas Smith
openaire   +1 more source

B-032 Validation of Polyethylene-glycol (PEG) precipitation for the prolactin assay to exclude macroprolactin on the Beckmann DXI800

Clinical Chemistry
Hyperprolactinemia is characterized by elevated serum prolactin levels due to a variety of systemic conditions. It has been associated with pituitary disorders, advanced liver dysfunction, cirrhosis, and chronic renal failure.
K. Lam, Dominique Ramos, Gene Usher, V. Dizon, D. Palmer-Toy   +4 more
semanticscholar   +1 more source

Reactivity of macroprolactin in common automated immunoassays

Clinical Biochemistry, 2001
To evaluate a simple assay for macroprolactin for use with the Bayer Immuno 1 analyzer, and to compare the reactivity of macroprolactin in commonly used automated prolactin assays.Macroprolactin in serum was precipitated in a buffer containing 13.3% polyethylene glycol (PEG) 8000, redissolved, and assayed on the Bayer Immuno 1 for PRL.
W, Schneider, S, Marcovitz, S, Al-Shammari, S, Yago, S, Chevalier   +4 more
openaire   +2 more sources

A-071 Macroprolactin Screening in Patients with Hyperprolactinemia: Comparison Between Different Criteria for Defining Macroprolactinemia

Clinical Chemistry
Prolactin (PRL) exists in different forms in human serum. The predominant form is monomeric PRL, the other forms include dimeric PRL and polymeric PRL, also known as macroprolactin, a biologically inactive form.
A. Correa Wengerkievicz Lopes, M. F. Pinheiro, T. Souza, P. T. Dias, R. Fontes, A. Perozo, Y. Schrank, D. Gomes, M. Castelo   +8 more
semanticscholar   +1 more source

Establishment of PCOS-specific prolactin reference intervals to optimize laboratory demand management for macroprolactin screening.

Clinical Biochemistry
BACKGROUND AND AIM Women with polycystic ovary syndrome (PCOS) often have elevated prolactin serum concentrations. This can lead to unnecessary macroprolactin screening and diagnostic confusion.
S. María, Durán-Espín Sofía, Tauler-Quetglas Paula, Alía-Ramos Pedro, F. Barbara   +4 more
semanticscholar   +1 more source

Serum prolactin and macroprolactin levels in diabetic nephropathy

Clinical Nephrology, 2012
Three molecular forms of prolactin with molecular weights of 23 (monomeric), 50 - 60 and > 100 kDA (macroprolactin) have been defined. Prolactin levels have been shown to be reduced in especially poorly controlled diabetes mellitus and the prevalence of macroprolactinemia in diabetic patients has been higher than the non-diabetic population.A total 234
Funda, Sari, Ramazan, Sari, Sebahat, Ozdem, Metin, Sarikaya, Ramazan, Cetinkaya   +4 more
openaire   +2 more sources

Cardiometabolic Risk Factors in Men with Elevated Macroprolactin Content: A Pilot Study.

Experimental and clinical endocrinology & diabetes, 2019
BACKGROUND Macroprolactinemia is a condition associated with the presence of large amounts of high molecular weight complexes of prolactin. Despite high prevalence, clinical significance of macroprolactin remains poorly understood. OBJECTIVE The aim of
R. Krysiak, W. Szkróbka, B. Okopień
semanticscholar   +1 more source

Macroprolactin screening in 464 patients with hyperprolactinaemia.

The Malaysian journal of pathology, 2022
Macroprolactinaemia is usually detected by polyethylene glycol (PEG) precipitation in clinical laboratories. Laboratory data on prolactin and macroprolactin screening by PEG precipitation in a tertiary hospital were reviewed in order to revise the local policy for reflex screening and reporting of macroprolactin in patients with hyperprolactinaemia ...
M H, Lim, C K M, Ho
openaire   +1 more source

Macroprolactin; high molecular mass forms of circulating prolactin

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2005
Two high molecular mass forms of prolactin (PRL) in serum have been identified by gel filtration chromatography (GFC): macroprolactin (big-big PRL, > 100 kDa) and big PRL (40-60 kDa). Macroprolactin has a variable composition and structure, but is most frequently a complex of PRL and IgG, with a molecular mass of 150-170 kDa.
M N, Fahie-Wilson, R, John, A R, Ellis
openaire   +2 more sources