Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration
Neural Regeneration Research, 2020 The retina may suffer neurodegenerative damages, as other tissues of the central nervous system do, and serious eye diseases may develop. One of them is age-related macular degeneration, which causes progressive loss of vision due to retina degeneration.
Francisco Bosch-Morell +9 more
doaj +1 more source
Widening use of dexamethasone implant for the treatment of macular edema [PDF]
, 2017 Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis.
Avitabile T. +9 more
core +2 more sources
Autophagy Impairment in Retinal Ganglion Cells Following Hypoglycemia in Mice
Cells(1) Background: Diabetic retinopathy (DR), caused by hypo- and hyperglycaemia, is the leading cause of blindness. Hypoglycemia induces endoplasmic reticulum stress and retinal cell death in mice, and low-glucose conditions induce macroautophagy/autophagy
Daria Fresia +4 more
doaj +1 more source
PLoS ONE, 2020 PURPOSE:The aim of this study was to investigate the association between refractive error and prevalence of age-related macular degeneration (AMD) in Korean adults, based on the sex and age group.
Kook Lee +4 more
doaj +1 more source
Vascular Response to Sildenafil Citrate in Aging and Age-Related Macular Degeneration. [PDF]
, 2019 Age-related macular degeneration (AMD) - the leading cause of vision loss in the elderly - share many risks factors as atherosclerosis, which exhibits loss of vascular compliance resulting from aging and oxidative stress.
Agrawal, Rupesh +8 more
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Morphometric analyses of the visual pathways in macular degeneration
, 2014 Introduction. Macular degeneration (MD) causes central visual field loss. When field defects occur in both eyes and overlap, parts of the visual pathways are no longer stimulated.
Baseler, Heidi A. +8 more
core +2 more sources
Blindness incidence in Germany - A population-based study from Württemberg-Hohenzollern [PDF]
, 1999 Few data on the incidence of blindness in Germany are available. We analysed causes of legal blindness for the region Württemberg-Hohenzollern (population 5.5 million) in order to help fill in this gap.
Klauss, V. +4 more
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A variance components factor model for genetic association studies: a Bayesian analysis.
, 2010 Studies of gene-trait associations for complex diseases often involve multiple traits that may vary by genotype groups or patterns. Such traits are usually manifestations of lower-dimensional latent factors or disease syndromes.
Nonyane, BAS, Whittaker, JC
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Optical Coherence Tomographic Angiography Imaging in Age-Related Macular Degeneration. [PDF]
, 2017 Optical coherence tomographic angiography (OCTA) is emerging as a rapid, noninvasive imaging modality that can provide detailed structural and flow information on retinal and choroidal vasculature.
Desai, Ria +5 more
core +3 more sources
Association of sildenafil use with age-related macular degeneration: a retrospective cohort study
BMJ Open OphthalmologyObjective Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)—a major cause of global blindness—lacks effective treatment to prevent the irreversible degeneration of ...
Nicola Jaime Adderley +6 more
doaj +1 more source